10 days in Northeast Missouri & Southeast Missouri Itinerary

Test the local claim that Saint Louis is second only to Washington, D.C.

Discover out-of-the-way places like Food Tours and Frank Lloyd Wright House in Ebsworth Park. Explore Saint Louis' surroundings by going to World Bird Sanctuary (in Valley Park) and Castlewood State Park (in Ballwin). The adventure continues: take an in-depth tour of Jefferson Barracks Telephone Museum, steep yourself in history at Jefferson National Expansion Memorial Park, browse the fresh offerings at Kirkwood Farmers’ Market, and walk around Laumeier Sculpture Park.

For reviews and tourist information, read our Saint Louis journey planner.

New York City to Saint Louis is an approximately 5.5-hour flight. You can also drive; or take a bus. Due to the time zone difference, you'll gain 1 hour traveling from New York City to Saint Louis. Plan for a bit cooler nights when traveling from New York City in November since evenings lows in Saint Louis dip to 35°F. Finish up your sightseeing early on the 19th (Thu) so you can travel to Cape Girardeau.

Cape Girardeau is a city in Cape Girardeau and Scott counties in the U.S. Start off your visit on the 20th (Fri): admire the majestic nature at Trail of Tears State Park, identify plant and animal life at Cape Girardeau Conservation Nature Center, and then make a trip to Missouri Wall of Fame.

To see photos, ratings, more things to do, and tourist information, you can read our Cape Girardeau attractions planner.

Traveling by car from Saint Louis to Cape Girardeau takes 2 hours. In November, plan for daily highs up to 57°F, and evening lows to 36°F. Cap off your sightseeing on the 20th (Fri) early enough to go by car to Sainte Genevieve.

Ste. On the 21st (Sat), get engrossed in the history at Bolduc House Museum, then admire the majestic nature at Hawn State Park, and then identify plant and animal life at Pickle Springs Natural Area.

To see traveler tips, reviews, maps, and more tourist information, use the Sainte Genevieve planning tool.

Getting from Cape Girardeau to Sainte Genevieve by car takes about 1.5 hours. In November, plan for daily highs up to 54°F, and evening lows to 36°F. Finish your sightseeing early on the 21st (Sat) so you can travel to Hermann.

Hermann is a city designated in 1842 as the county seat of Gasconade County, Missouri, United States. Kick off your visit on the 22nd (Sun): do a tasting at Endless Summer Winery, stop by Sugar Momma's, then awaken your taste buds at Hermann Wine Trail, and finally contemplate the long history of Deutschheim State Historic Site. On the 23rd (Mon), you'll have a packed day of sightseeing: appreciate the extensive heritage of John Colter Memorial, brush up on your knowledge of spirits at Pinckney Bend Distillery, learn about winemaking at Robller Vineyard, then sample the tasty concoctions at Tin Mill Brewing Company, and finally learn about winemaking at Adam Puchta Winery.

For where to stay, reviews, and other tourist information, refer to the Hermann trip itinerary site.

Drive from Sainte Genevieve to Hermann in 2.5 hours. Expect a daytime high around 56°F in November, and nighttime lows around 35°F. Finish up your sightseeing early on the 23rd (Mon) so you can travel to Hannibal.

Hannibal is a city in Marion and Ralls counties in the U.S. Kick off your visit on the 24th (Tue): examine the collection at Big River Train Town, see the interesting displays at Karlocks Kars and Pop Culture Museum, and then head outdoors with Lovers Leap. On the 25th (Wed), you'll have a packed day of sightseeing: examine the collection at Molly Brown Museum and Home, enjoy the sea views from Mark Twain Memorial Lighthouse, and then appreciate the history behind Tom Sawyer' Statue.

For where to stay, other places to visit, and other tourist information, refer to the Hannibal trip itinerary maker website.

Drive from Hermann to Hannibal in 2 hours. In November, plan for daily highs up to 55°F, and evening lows to 36°F. Finish up your sightseeing early on the 25th (Wed) so you can travel back home.