10 days in Northeast Missouri & Southeast Missouri Itinerary

Test the local claim that Saint Louis is second only to Washington, D.C.

Escape the urban bustle at World Bird Sanctuary and The Sophia M. Sachs Butterfly House. You'll explore the less-touristy side of things at Food Tours and Frank Lloyd Wright House in Ebsworth Park. Step out of Saint Louis with an excursion to Castlewood State Park in Ballwin--about 34 minutes away. There's still lots to do: get engrossed in the history at The National Museum of Transportation, admire the striking features of Jefferson National Expansion Memorial Park, sample the tasty concoctions at Anheuser-Busch Brewery, and take in the pleasant sights at St. Louis Graffiti Wall.

To see reviews, other places to visit, photos, and more tourist information, you can read our Saint Louis travel planner.

New York City to Saint Louis is an approximately 5.5-hour flight. You can also drive; or take a bus. Traveling from New York City to Saint Louis, you'll gain 1 hour due to the time zone difference. Expect a bit cooler evenings in Saint Louis when traveling from New York City in November, with lows around 35°F. Finish your sightseeing early on the 30th (Mon) to allow enough time to drive to Sainte Genevieve.

Ste. On the 1st (Tue), take an in-depth tour of Bolduc House Museum, admire the majestic nature at Hawn State Park, and then identify plant and animal life at Pickle Springs Natural Area.

To find traveler tips, where to stay, photos, and more tourist information, go to the Sainte Genevieve itinerary builder.

Getting from Saint Louis to Sainte Genevieve by car takes about 1.5 hours. November in Sainte Genevieve sees daily highs of 54°F and lows of 36°F at night. Finish up your sightseeing early on the 1st (Tue) so you can go by car to Cape Girardeau.

Cape Girardeau is a city in Cape Girardeau and Scott counties in the U.S. Start off your visit on the 2nd (Wed): immerse yourself in nature at Trail of Tears State Park, look for all kinds of wild species at Cape Girardeau Conservation Nature Center, and then make a trip to Missouri Wall of Fame.

To find other places to visit, photos, traveler tips, and tourist information, use the Cape Girardeau trip tool.

You can drive from Sainte Genevieve to Cape Girardeau in 1.5 hours. In December, plan for daily highs up to 47°F, and evening lows to 30°F. Wrap up your sightseeing on the 2nd (Wed) to allow time to travel to Eminence.

Eminence is a city in Shannon County, Missouri, United States. On the 3rd (Thu), explore the striking landscape of Alley Spring Grist Mill Historic Site. On your second day here, explore the activities along Blue Spring and then admire the majestic nature at Echo Bluff State Park.

For photos, maps, and more tourist information, read our Eminence road trip site.

Drive from Cape Girardeau to Eminence in 3 hours. In December, daily temperatures in Eminence can reach 48°F, while at night they dip to 29°F. Finish your sightseeing early on the 4th (Fri) so you can travel to Hermann.

Hermann is a city designated in 1842 as the county seat of Gasconade County, Missouri, United States. Start off your visit on the 5th (Sat): get to know the fascinating history of John Colter Memorial, brush up on your knowledge of spirits at Pinckney Bend Distillery, learn about winemaking at Robller Vineyard, then pick up a one of a kind souvenir at Hermann's Attic Antique Mall, and finally do a tasting at Adam Puchta Winery. On your second day here, look for gifts at Sugar Momma's, indulge your senses at Hermann Wine Trail, then steep yourself in history at Deutschheim State Historic Site, and finally sample the tasty concoctions at Tin Mill Brewing Company.

To see more things to do, where to stay, traveler tips, and more tourist information, read our Hermann trip builder.

Getting from Eminence to Hermann by car takes about 3 hours. In December in Hermann, expect temperatures between 44°F during the day and 27°F at night. Wrap up your sightseeing on the 6th (Sun) early enough to travel back home.