14 days in Northeast Missouri, Southeast Missouri & Central Missouri Itinerary

Test the local claim that Saint Louis is second only to Washington, D.C.

Head to Soulard Farmers Market and Kirkwood Farmers’ Marketfor plenty of shopping. Step off the beaten path and head to Food Tours and National Blues Museum. And it doesn't end there: take in the architecture and atmosphere at Cathedral Basilica of Saint Louis, savor the flavors at Food & Drink, stroll around Forest Park, and take in panoramic vistas at The Gateway Arch.

To see traveler tips, ratings, more things to do, and more tourist information, refer to the Saint Louis trip maker.

The Route module can give you travel options from your home to Saint Louis. In November, daily temperatures in Saint Louis can reach 56°F, while at night they dip to 35°F. Finish your sightseeing early on the 19th (Thu) to allow enough time to drive to Sainte Genevieve.

Ste. Start off your visit on the 20th (Fri): take an in-depth tour of Bolduc House Museum, immerse yourself in nature at Hawn State Park, and then look for all kinds of wild species at Pickle Springs Natural Area.

For other places to visit, ratings, more things to do, and more tourist information, refer to the Sainte Genevieve day trip planning site.

You can drive from Saint Louis to Sainte Genevieve in 1.5 hours. In November, daily temperatures in Sainte Genevieve can reach 54°F, while at night they dip to 36°F. Finish your sightseeing early on the 20th (Fri) so you can travel to Saint Robert.

Explore hidden gems such as St. James Winery and Alley Spring Grist Mill Historic Site. Venture out of the city with trips to Ha Ha Tonka State Park (in Camdenton), Lake of the Ozarks State Park (in Kaiser) and Fanning 66 Outpost (in Cuba).

To find reviews, traveler tips, other places to visit, and more tourist information, go to the Saint Robert trip builder tool.

Traveling by car from Sainte Genevieve to Saint Robert takes 2.5 hours. Expect a daytime high around 56°F in November, and nighttime lows around 35°F. Wrap up your sightseeing on the 23rd (Mon) to allow time to travel to Columbia.

Columbia is a city in the U.S. You'll discover tucked-away gems like The National Churchill Museum and Lewis and Clark Monument Trailhead Plaza. Explore Columbia's surroundings by going to Jefferson City (Runge Conservation Nature Center & Missouri State Penitentiary). And it doesn't end there: sample some tasty brews at Columbia Culinary Tours, learn about winemaking at Serenity Valley Winery, admire the majestic nature at Rock Bridge Memorial State Park, and take in nature's colorful creations at Shelter Gardens.

To find photos, maps, traveler tips, and tourist information, you can read our Columbia vacation planner.

You can drive from Saint Robert to Columbia in 2 hours. In November, daily temperatures in Columbia can reach 56°F, while at night they dip to 35°F. Finish your sightseeing early on the 26th (Thu) to allow enough time to drive to Hermann.

Hermann is a city designated in 1842 as the county seat of Gasconade County, Missouri, United States. Kick off your visit on the 27th (Fri): whizz through the canopy at some of the top local zipline courses and adventure parks, steep yourself in history at Deutschheim State Historic Site, then indulge your senses at Hermann Wine Trail, then stop by Sugar Momma's, and finally browse for treasures at Hermann's Attic Antique Mall. On the next day, brush up on your knowledge of spirits at Wood Hat Spirits Distillery, do a tasting at Robller Vineyard, then brush up on your knowledge of spirits at Pinckney Bend Distillery, then take in the exciting artwork at Astral Glass Studio and Gallery, and finally appreciate the extensive heritage of John Colter Memorial.

To find maps, other places to visit, ratings, and more tourist information, read Hermann vacation planner.

Drive from Columbia to Hermann in 1.5 hours. In November in Hermann, expect temperatures between 56°F during the day and 35°F at night. Wrap up your sightseeing on the 28th (Sat) to allow time to drive back home.