14 days in South Carolina, Southeast Missouri & Tennessee Itinerary

14 days in South Carolina, Southeast Missouri & Tennessee Itinerary

Created using Inspirock United States trip planner

Make it your trip
Fly
1
Myrtle Beach
— 1 night
Drive
2
Charleston
— 5 nights
Drive
3
Cape Girardeau
— 2 nights
Drive
4
Gatlinburg
— 5 nights
Fly

S M T W T F S
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28

Myrtle Beach

— 1 night
Myrtle Beach is a coastal city on the east coast of the United States in Horry County, South Carolina. On the 15th (Sun), look for all kinds of wild species at Alligator Adventure and then surround yourself with nature on a nature and wildlife tour. Get ready for a full day of sightseeing on the 16th (Mon): learn the secrets of beer at East Coast BrewBoat, then admire the majestic nature at Huntington Beach State Park, and then immerse yourself in nature at Myrtle Beach State Park.

For other places to visit, traveler tips, reviews, and other tourist information, use the Myrtle Beach trip itinerary tool.

New York City to Myrtle Beach is an approximately 3.5-hour flight. You can also drive; or do a combination of train and car. When traveling from New York City in November, plan for somewhat warmer days and about the same nights in Myrtle Beach: temperatures range from 66°F by day to 46°F at night. Finish your sightseeing early on the 16th (Mon) to allow enough time to drive to Charleston.

Things to do in Myrtle Beach

Parks · Nature · Wildlife · Tours

Side Trips

Charleston

— 5 nights
Many visitors describe their Charleston holiday as a warm embrace by an old, dear friend--who lived about 200 years ago.
Visiting Horse-Drawn Carriage Tours and Botany Bay Plantation Heritage Preserve and Wildlife Management Area will get you outdoors. Discover out-of-the-way places like Stand-Up Paddleboarding and Angel Oak Tree. Get out of town with these interesting Charleston side-trips: Hunting Island State Park (in Beaufort), Edisto Beach State Park (in Edisto Island) and Charleston Tea Garden (in Wadmalaw Island). Next up on the itinerary: play a few rounds at Kiawah Island, ponder the design of Pineapple Fountain, make a trip to Rainbow Row, and take in the exciting artwork at Meyer Vogl Gallery.

For photos, more things to do, ratings, and tourist information, read Charleston day trip planning site.

Traveling by car from Myrtle Beach to Charleston takes 2.5 hours. Alternatively, you can take a bus. In November in Charleston, expect temperatures between 68°F during the day and 49°F at night. Wrap up your sightseeing by early afternoon on the 21st (Sat) to allow time for travel to Cape Girardeau.

Things to do in Charleston

Parks · Nature · Outdoors · Tours

Side Trips

Cape Girardeau

— 2 nights
Cape Girardeau is a city in Cape Girardeau and Scott counties in the U.S. state of Missouri. Start off your visit on the 22nd (Sun): tour the pleasant surroundings at Cape LaCroix Recreation Trail, then hike along Trail of Tears, and then contemplate in the serene atmosphere at Old St.Vincent's Church. Get ready for a full day of sightseeing on the next day: walk around A.C. Brase Arena Building & Park and then immerse yourself in nature at Trail of Tears State Park.

For where to stay, ratings, traveler tips, and more tourist information, go to the Cape Girardeau trip builder.

Traveling by car from Charleston to Cape Girardeau takes 12 hours. Alternatively, you can do a combination of car and flight. You'll gain 1 hour traveling from Charleston to Cape Girardeau due to the time zone difference. Traveling from Charleston in November, expect Cape Girardeau to be little chillier, temps between 57°F and 36°F. Wrap up your sightseeing on the 23rd (Mon) to allow time to travel to Gatlinburg.

Things to do in Cape Girardeau

Parks · Trails · Outdoors · Nature

Side Trip

Gatlinburg

— 5 nights

The Gateway to the Great Smoky Mountains

Nestled in the lush, wooded forests of the Great Smoky Mountains National Park, Gatlinburg is Tennessee’s premier mountain resort destination.
Take a break from the city and head to Clingmans Dome and Gatlinburg Scenic Overlook. Explore hidden gems such as Great Smoky Mountains National Park and Roaring Fork Motor Nature Trail. Explore Gatlinburg's surroundings by going to Foothills Parkway Southwest Parking (in Great Smoky Mountains National Park) and Tuckaleechee Caverns (in Townsend). There's still lots to do: tour the pleasant surroundings at Gatlinburg Trail, brush up on your knowledge of spirits at Tennessee Shine Company - Gatlinburg, trek along Rainbow Falls Trail, and kick your exploration up a notch at some of the top local zipline courses and adventure parks.

To find where to stay, traveler tips, ratings, and tourist information, read Gatlinburg travel planner.

Getting from Cape Girardeau to Gatlinburg by car takes about 7 hours. Other options: do a combination of car and flight. Due to the time zone difference, you'll lose 1 hour traveling from Cape Girardeau to Gatlinburg. November in Gatlinburg sees daily highs of 60°F and lows of 39°F at night. Cap off your sightseeing on the 28th (Sat) early enough to catch the flight back home.

Things to do in Gatlinburg

Parks · Outdoors · Nature · Trails

Side Trips

South Carolina travel guide

4.3
Historic Sites · Dolphin & Whale Watching · Gardens
The Palmetto State
Composed of five distinct geographic regions with boundaries roughly parallel to the Atlantic coastline, South Carolina embraces rich history, scenic beauty, and outstanding cuisine. Originally established as a slave society dependent on the cultivation of rice and indigo, the state now boasts a diverse economy that includes massive production of textile goods, chemical products, machinery, and automobiles. Widely regarded as the beginning of the Deep South, the state remains a deeply conservative part of the country, fervently clinging to its religious and cultural traditions. South Carolinians are kind and open hosts to those who vacation here, eager to share the wealth of their cultural heritage with curious visitors. With many remarkable places to visit like Charleston and Hilton Head, your itinerary here is sure to be diverse and full of scenic attractions.

Tennessee travel guide

4.4
Specialty Museums · Distilleries · Theaters
The Volunteer State
Divided by law, geography, and custom into three major regions, represented by the three stars on state's flag, Tennessee boasts a distinctive musical heritage that includes elements of bluegrass, country-western, and blues. With a countryside as diverse as its people, Tennessee includes landscapes ranging from a mountainous region in the east to the lowlands of the west, with gently rolling hills in the middle. For a well-rounded vacation, you can hike remote mountain trails in the morning and explore the crowded bars of Nashville in the evening. Visit the urban attractions, such as Elvis Presley's former residence in Memphis, but don't miss a chance to spend some time in the Great Smoky Mountains National Park, situated in the eastern part of the state.