14 days in Tennessee, North Carolina & South Carolina Itinerary

14 days in Tennessee, North Carolina & South Carolina Itinerary

Created using Inspirock United States itinerary planner

Make it your trip
Drive
1
Gatlinburg
— 3 nights
Drive
2
Asheville
— 2 nights
Drive
3
Hilton Head
— 3 nights
Unknown
4
Edisto Island
— 2 nights
Drive
5
Charleston
— 2 nights
Drive
6
North Myrtle Beach
Drive

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Gatlinburg

— 3 nights

The Gateway to the Great Smoky Mountains

Nestled in the lush, wooded forests of the Great Smoky Mountains National Park, Gatlinburg is Tennessee’s premier mountain resort destination.
Get outdoors at Roaring Fork and Gatlinburg Trail. Discover out-of-the-way places like Newfound Gap Road and Chimney Tops Trail. Change things up with a short trip to Tennessee Legend Distillery - Newport Hwy in Sevierville (about 34 minutes away). The adventure continues: sample the fine beverages at Sugarlands Distilling Company, learn about winemaking at Tennessee Homemade Wines, and cruise along Gatlinburg Scenic Overlook.

To see ratings, photos, where to stay, and tourist information, read Gatlinburg route site.

Saint Louis to Gatlinburg is an approximately 7-hour flight. You can also drive; or do a combination of bus, subway, and car. Due to the time zone difference, you'll lose 1 hour traveling from Saint Louis to Gatlinburg. November in Gatlinburg sees daily highs of 60°F and lows of 39°F at night. Cap off your sightseeing on the 18th (Wed) early enough to go by car to Asheville.

Things to do in Gatlinburg

Outdoors · Parks · Trails · Wineries

Side Trips

Asheville

— 2 nights

Land of the Sky

Asheville nestles between two major mountain ranges in the scenic western section of North Carolina.
Kick off your visit on the 19th (Thu): take a memorable tour with Tours and then admire the verdant scenery at Pearson's Falls and Glen. Get ready for a full day of sightseeing on the 20th (Fri): get interesting insight from Tumblestone Tours and Transportation and then sample some tasty brews at BREW-ed.

To see traveler tips, where to stay, other places to visit, and tourist information, you can read our Asheville trip planner.

You can drive from Gatlinburg to Asheville in 2 hours. November in Asheville sees daily highs of 59°F and lows of 36°F at night. Finish your sightseeing early on the 20th (Fri) to allow enough time to drive to Hilton Head.

Things to do in Asheville

Tours · Wildlife · Outdoors · Breweries & Distilleries

Side Trip

Hilton Head

— 3 nights
A Hilton Head vacation may be heaven for a golfer, but the area also offers all kinds of other options for sports fans.
Kick off your visit on the 21st (Sat): stroll around Folly Field Beach Park, then see majestic marine mammals with May River Excursions, and then play a few rounds at Hilton Head National. On your second day here, enjoy the sand and surf at Driessen Beach Park, then enjoy the sand and surf at Burkes Beach, then indulge your senses at Carolina Tasting Room, and finally stop by Mingles.

For traveler tips, other places to visit, where to stay, and other tourist information, go to the Hilton Head online travel route planner.

Getting from Asheville to Hilton Head by car takes about 6 hours. Other options: drive; or fly; or take a bus. Prepare for a bit warmer weather when traveling from Asheville in November: high temperatures in Hilton Head hover around 68°F and lows are around 51°F. On the 23rd (Mon), you'll have the morning to explore before heading off to Edisto Island.

Things to do in Hilton Head

Outdoors · Beaches · Parks · Tours

Side Trip

Edisto Island

— 2 nights
Edisto Island is one of South Carolina's Sea Islands, the larger part of which lies in Charleston County, with its southern tip in Colleton County. Visiting Botany Bay Plantation Heritage Preserve and Wildlife Management Area and Fontaine Charters will get you outdoors. Discover out-of-the-way places like Edisto Beach State Park and The Marina at Edisto Beach. Go for a jaunt from Edisto Island to Johns Island to see Low Tide Brewing about 44 minutes away. Next up on the itinerary: trek along Indian Mound Trail, play a few rounds at The Plantation Course at Edisto, and stop by With These Hands Gallery.

To see where to stay, more things to do, other places to visit, and tourist information, read our Edisto Island day trip planner.

You can travel from Hilton Head to Edisto Island in 2 hours. November in Edisto Island sees daily highs of 68°F and lows of 49°F at night. Cap off your sightseeing on the 25th (Wed) early enough to go by car to Charleston.

Things to do in Edisto Island

Parks · Outdoors · Wildlife · Trails

Side Trip

Charleston

— 2 nights
Many visitors describe their Charleston holiday as a warm embrace by an old, dear friend--who lived about 200 years ago.
On the 26th (Thu), find your balance on the water with some of the best stand-up paddleboarding in the area, take in the dramatic natural features at Angel Oak Tree, and then get thoroughly spooked out with a ghost and vampire tour. Keep things going the next day: settle in for a delightful tour with a horse-drawn carriage tour, then don't miss a visit to Charleston Fire Department, Station 2/3, then step off the mainland to explore Kiawah Island, and finally make a trip to Pineapple Fountain.

Plan a Charleston trip in moments using our itinerary builder.

You can drive from Edisto Island to Charleston in 1.5 hours. In November, daily temperatures in Charleston can reach 68°F, while at night they dip to 49°F. Wrap up your sightseeing on the 27th (Fri) to allow time to drive to North Myrtle Beach.

Things to do in Charleston

Outdoors · Tours · Nature · Parks

Side Trips

North Myrtle Beach

North Myrtle Beach is a city in Horry County, South Carolina, United States. For maps, ratings, and other tourist information, use the North Myrtle Beach itinerary planner.

Getting from Charleston to North Myrtle Beach by car takes about 3 hours. Other options: do a combination of bus and taxi. Expect a daytime high around 67°F in November, and nighttime lows around 45°F. You'll set off for home on the 27th (Fri).

Things to do in North Myrtle Beach

Outdoors · Tours · Golf · Nightlife

Tennessee travel guide

4.4
Specialty Museums · Distilleries · Theaters
The Volunteer State
Divided by law, geography, and custom into three major regions, represented by the three stars on state's flag, Tennessee boasts a distinctive musical heritage that includes elements of bluegrass, country-western, and blues. With a countryside as diverse as its people, Tennessee includes landscapes ranging from a mountainous region in the east to the lowlands of the west, with gently rolling hills in the middle. For a well-rounded vacation, you can hike remote mountain trails in the morning and explore the crowded bars of Nashville in the evening. Visit the urban attractions, such as Elvis Presley's former residence in Memphis, but don't miss a chance to spend some time in the Great Smoky Mountains National Park, situated in the eastern part of the state.

North Carolina travel guide

4.4
Historic Sites · Specialty Museums · Zipline
The Tar Heel State
A top destination for a holiday in nature, North Carolina provides a seemingly endless variety of outdoor activities, including hiking, mountain climbing, and skiing. While the state's rural regions offer a taste of traditional Appalachian music and culture, its increasingly diverse big cities feature modern skyscrapers, renowned museums, and historical neighborhoods perfect for sightseeing tours. The coastal region, famous for its year-round temperate climate, attracts millions of annual visitors, making North Carolina the sixth most-visited state in the country. Though it's hard to find a quiet time of year in coastal North Carolina, the state's inland areas retain many secluded corners where you can experience the laid-back Old South atmosphere.

South Carolina travel guide

4.3
Historic Sites · Dolphin & Whale Watching · Gardens
The Palmetto State
Composed of five distinct geographic regions with boundaries roughly parallel to the Atlantic coastline, South Carolina embraces rich history, scenic beauty, and outstanding cuisine. Originally established as a slave society dependent on the cultivation of rice and indigo, the state now boasts a diverse economy that includes massive production of textile goods, chemical products, machinery, and automobiles. Widely regarded as the beginning of the Deep South, the state remains a deeply conservative part of the country, fervently clinging to its religious and cultural traditions. South Carolinians are kind and open hosts to those who vacation here, eager to share the wealth of their cultural heritage with curious visitors. With many remarkable places to visit like Charleston and Hilton Head, your itinerary here is sure to be diverse and full of scenic attractions.