15 days in Florida Itinerary

15 days in Florida Itinerary

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Route & dates

15 days in Florida Itinerary

Start: Cayenne
Fly + Drive:  16​h 15​min
1
Key Largo
— 1 night
Drive:  45​min
2
Islamorada
— 2 nights
Drive:  45​min
3
Marathon
— 3 nights
bus + Fly:  6​h 15​min
4
Panama City Beach
— 1 night
Drive:  5​h 30​min
5
St. Augustine
— 1 night
Drive:  6​h
6
Marco Island
— 1 night
Drive + Fly:  18​h
End: Cayenne

1
night
Key Largo

The northernmost island of the Florida Keys, Key Largo provides stunning scenery, a number of watersports opportunities, and plenty of areas to relax on vacation.
Here are some ideas for day two: look for gifts at florida keys key lime products, then glide through the air with a parasailing or paragliding tour, and then identify plant and animal life at Anhinga Trail.

Quickly create a custom-made itinerary for Key Largo using our trip planner.

Cayenne, French Guiana to Key Largo is an approximately 16.5-hour flight. You'll gain 2 hours traveling from Cayenne to Key Largo due to the time zone difference. In May, daily temperatures in Key Largo can reach 34°C, while at night they dip to 26°C. Cap off your sightseeing on the 15th (Wed) early enough to go by car to Islamorada.

Things to do in Key Largo

Outdoors Tours Adventure

Side Trip

Anhinga Trail
Highlights from your plan
Parasailing & Paragliding
Anhinga Trail ©
Anhinga Trail
florida keys key lime products ©
florida keys key lime products

2
nights
Islamorada

Islamorada, long recognized as one of the world's top spots for sport fishing, encompasses six islands in the Florida Keys.
Kick off your visit on the 16th (Thu): identify plant and animal life at Wildlife Areas and then see what you can catch with a fishing tour. Keep things going the next day: take in the exciting artwork at Old Road Gallery, glide peacefully along the water with some of the best stand-up paddleboarding in the area, explore the gorgeous colors at Alligator Reef Light House, then take a tour by water with Boat Tours & Water Sports, and finally view the masterpieces at Michelle Nicole Lowe Art Gallery.

To find more things to do and tourist information, go to the Islamorada holiday maker tool .

Drive from Key Largo to Islamorada in an hour. Alternatively, you can do a combination of taxi and bus. Expect a daytime high around 36°C in May, and nighttime lows around 29°C. Cap off your sightseeing on the 17th (Fri) early enough to go by car to Marathon.

Things to do in Islamorada

Outdoors Tours Wildlife
Highlights from your plan
Fishing Charters & Tours
Alligator Reef Light House ©
Alligator Reef Light House
Stand-Up Paddleboarding

3
nights
Marathon

Marathon ©
A tiny city just 16 km (10 mi) long, Marathon is spread across several islands in the middle of the Florida Keys.
Your itinerary includes some good beach time at Bahia Honda State Park and Sombrero Beach. Take a break from the city and head to Sombrero Reef and Dolphin Research Center. There's still lots to do: look for all kinds of wild species at Crane Point Museum & Nature Center, cast your line with a fishing tour, kick back and relax at Sunset Park Beach, and take in the views from Seven Mile Bridge.

Plan trip to Marathon with our itinerary maker to find out where to go and what to do.

Drive from Islamorada to Marathon in an hour. Alternatively, you can take a bus. May in Marathon sees daily highs of 36°C and lows of 29°C at night. Finish your sightseeing early on the 20th (Mon) so you can travel to Panama City Beach.

Things to do in Marathon

Parks Wildlife Outdoors

Side Trips

Sunset Park Beach, Bahia Honda State Park
Highlights from your plan
Crane Point Museum & Nature Center ©
Sombrero Reef ©
Sombrero Reef
Sunset Park Beach ©
Sunset Park Beach

1
night
Panama City Beach

Panama City Beach ©
Boasting 43 km (27 mi) of white sandy beaches and plenty of sunshine, Panama City Beach is an ideal choice for a relaxing holiday.
Kick off your visit on the 21st (Tue): view the masterpieces at Paul Brent Gallery, then take a tour by water with Boat Tours & Water Sports, and then get up close to creatures of the deep with a dolphin and whale watching tour. Keep things going the next day: meet the residents at Gulf World Marine Park, then buy something for everyone on your list at Pier Park, then learn about winemaking at Panama City Beach Winery, and finally immerse yourself in nature at St. Andrews State Park.

For more things to do, where to stay, and tourist information, read Panama City Beach vacation planning app .

Do a combination of bus and flight from Marathon to Panama City Beach in 6.5 hours. Alternatively, you can do a combination of shuttle, flight, and car; or drive. Traveling from Marathon in May, expect slightly colder with lows of 19°C in Panama City Beach. Wrap up your sightseeing on the 22nd (Wed) early enough to drive to St. Augustine.

Things to do in Panama City Beach

Outdoors Wildlife Tours

Side Trip

Paul Brent Gallery
Highlights from your plan
Panama City Beach Winery ©
Panama City Beach Winery
Dolphin & Whale Watching
Swim with Dolphins

1
night
St. Augustine

St. Augustine ©
SAINT AUGUSTINE | PONTE VEDRA on Florida's Historic Coast The Nation's oldest city (est. Kick off your visit on the 23rd (Thu): identify plant and animal life at St. Augustine Alligator Farm Zoological Park, stroll through St. Augustine Beach, then examine the collection at St. Augustine Pirate & Treasure Museum, and finally look for gifts at Market to Market. Keep things going the next day: explore the striking landscape of Fort Matanzas National Monument.

For more things to do, ratings, maps, and more tourist information, read our St. Augustine trip builder website .

You can drive from Panama City Beach to St. Augustine in 5.5 hours. Alternatively, you can do a combination of flight and bus; or do a combination of taxi, flight, and bus. In May, plan for daily highs up to 33°C, and evening lows to 22°C. Wrap up your sightseeing on the 24th (Fri) early enough to drive to Marco Island.

Things to do in St. Augustine

Parks Nature Historic Sites
Highlights from your plan
St. Augustine Beach ©
St. Augustine Beach

1
night
Marco Island

Marco Island ©
Marco Island is a city in Collier County, Florida, United States, located on an island by the same name in the Gulf of Mexico off the coast of Southwest Florida. Start off your visit on the 25th (Sat): enjoy the sand and surf at South Marco Beach, take a tour by water with Boat Tours & Water Sports, and then zoom along the surf with a waterskiing or jet-skiing adventure. Here are some ideas for day two: see what you can catch with a fishing tour and then see majestic marine mammals with a dolphin and whale watching tour.

To see traveler tips, other places to visit, maps, and tourist information, refer to the Marco Island visit planner .

You can drive from St. Augustine to Marco Island in 6 hours. Other options are to do a combination of car, flight, and bus; or do a combination of bus and flight. In May, daily temperatures in Marco Island can reach 36°C, while at night they dip to 24°C. Finish your sightseeing early on the 26th (Sun) to allow enough time to travel back home.

Things to do in Marco Island

Outdoors Tours Wildlife
Highlights from your plan
South Marco Beach ©
South Marco Beach
Dolphin & Whale Watching
Fishing Charters & Tours

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