15 days in North Carolina, South Carolina & Tennessee Itinerary

15 days in North Carolina, South Carolina & Tennessee Itinerary

Created using Inspirock United States trip itinerary planner

Make it your trip
Drive
1
Asheville
— 3 nights
Drive
2
Charleston
— 2 nights
Drive
3
Edisto Island
— 1 night
Unknown
4
Hilton Head
— 3 nights
Drive
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Gatlinburg
— 3 nights
Drive

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Asheville

— 3 nights

Land of the Sky

Asheville nestles between two major mountain ranges in the scenic western section of North Carolina.
Discover out-of-the-way places like The North Carolina Arboretum and BREW-ed. Escape the urban bustle at Tumblestone Tours and Transportation and Fishing Charters & Tours. Change things up with these side-trips from Asheville: Pearson's Falls and Glen (in Saluda) and Table Rock State Park (in Pickens). Next up on the itinerary: take in the exciting artwork at St.Claire Art.

For where to stay, maps, and other tourist information, you can read our Asheville day trip planning site.

Saint Louis to Asheville is an approximately 6.5-hour flight. You can also drive; or do a combination of bus, subway, and car. You'll lose 1 hour traveling from Saint Louis to Asheville due to the time zone difference. In November in Asheville, expect temperatures between 59°F during the day and 36°F at night. Finish up your sightseeing early on the 18th (Wed) so you can go by car to Charleston.

Things to do in Asheville

Tours · Wildlife · Outdoors · Parks

Side Trips

Charleston

— 2 nights
Many visitors describe their Charleston holiday as a warm embrace by an old, dear friend--who lived about 200 years ago.
Kick off your visit on the 18th (Wed): get a dose of the wild on Charleston Fossil Adventures, look for all kinds of wild species at Caw Caw Interpretive Center, and then admire the natural beauty at Washington Square. Keep things going the next day: tee off at The Ocean Course, step off the mainland to explore Kiawah Island, then explore the world behind art at City Gallery at Waterfront Park, and finally admire the local landmark of Pineapple Fountain.

To find maps, more things to do, other places to visit, and tourist information, go to the Charleston trip itinerary builder app.

Drive from Asheville to Charleston in 4.5 hours. Alternatively, you can do a combination of bus and flight; or take a bus. Prepare for a bit warmer weather when traveling from Asheville in November: high temperatures in Charleston hover around 68°F and lows are around 49°F. Finish up your sightseeing early on the 20th (Fri) so you can go by car to Edisto Island.

Things to do in Charleston

Outdoors · Wildlife · Parks · Golf

Side Trips

Edisto Island

— 1 night
Edisto Island is one of South Carolina's Sea Islands, the larger part of which lies in Charleston County, with its southern tip in Colleton County. Kick off your visit on the 20th (Fri): identify plant and animal life at Botany Bay Plantation Heritage Preserve and Wildlife Management Area, kick back and relax at Edisto Beach State Park, and then take a memorable tour with Fontaine Charters.

To find ratings, where to stay, other places to visit, and tourist information, refer to the Edisto Island vacation planner.

Traveling by car from Charleston to Edisto Island takes 1.5 hours. November in Edisto Island sees daily highs of 68°F and lows of 49°F at night. Cap off your sightseeing on the 21st (Sat) early enough to travel to Hilton Head.

Things to do in Edisto Island

Parks · Outdoors · Wildlife · Beaches

Hilton Head

— 3 nights
A Hilton Head vacation may be heaven for a golfer, but the area also offers all kinds of other options for sports fans.
Get in touch with nature at Hilton Head Island Bike Trails and Audubon Newhall Preserve. You'll discover tucked-away gems like Harbour Town Golf Links at Sea Pines and Fort Mitchel. Change things up with a short trip to Spanish Moss Trail in Beaufort (about 50 minutes away). There's still lots to do: indulge your senses at Carolina Tasting Room, get up close to creatures of the deep with May River Excursions, enjoy the sand and surf at Burkes Beach, and tee off at Hilton Head National.

To see other places to visit, photos, and tourist information, read our Hilton Head online tour itinerary builder.

You can travel from Edisto Island to Hilton Head in 2 hours. November in Hilton Head sees daily highs of 68°F and lows of 51°F at night. Finish up your sightseeing early on the 24th (Tue) so you can travel to Gatlinburg.

Things to do in Hilton Head

Outdoors · Parks · Trails · Golf

Side Trips

Gatlinburg

— 3 nights

The Gateway to the Great Smoky Mountains

Nestled in the lush, wooded forests of the Great Smoky Mountains National Park, Gatlinburg is Tennessee’s premier mountain resort destination.
Discover out-of-the-way places like Roaring Fork Motor Nature Trail and Gatlinburg Trail. Escape the urban bustle at Roaring Fork and Gatlinburg Scenic Overlook. Step out of Gatlinburg to go to Sevierville and see Tennessee Legend Distillery - Newport Hwy, which is approximately 34 minutes away. And it doesn't end there: take a memorable drive along Newfound Gap Road, brush up on your knowledge of spirits at Doc Collier Distillery, do a tasting at Mill Bridge Winery, and take in the dramatic natural features at Chimney Tops Trail.

To find photos, more things to do, and tourist information, you can read our Gatlinburg day trip tool.

Getting from Hilton Head to Gatlinburg by car takes about 7.5 hours. Other options: fly; or drive; or do a combination of bus and car. In November, Gatlinburg is a bit cooler than Hilton Head - with highs of 60°F and lows of 39°F. Finish your sightseeing early on the 27th (Fri) to allow enough time to travel back home.

Things to do in Gatlinburg

Parks · Outdoors · Trails · Wineries

Side Trips

North Carolina travel guide

4.4
Historic Sites · Specialty Museums · Zipline
The Tar Heel State
A top destination for a holiday in nature, North Carolina provides a seemingly endless variety of outdoor activities, including hiking, mountain climbing, and skiing. While the state's rural regions offer a taste of traditional Appalachian music and culture, its increasingly diverse big cities feature modern skyscrapers, renowned museums, and historical neighborhoods perfect for sightseeing tours. The coastal region, famous for its year-round temperate climate, attracts millions of annual visitors, making North Carolina the sixth most-visited state in the country. Though it's hard to find a quiet time of year in coastal North Carolina, the state's inland areas retain many secluded corners where you can experience the laid-back Old South atmosphere.

South Carolina travel guide

4.3
Historic Sites · Dolphin & Whale Watching · Gardens
The Palmetto State
Composed of five distinct geographic regions with boundaries roughly parallel to the Atlantic coastline, South Carolina embraces rich history, scenic beauty, and outstanding cuisine. Originally established as a slave society dependent on the cultivation of rice and indigo, the state now boasts a diverse economy that includes massive production of textile goods, chemical products, machinery, and automobiles. Widely regarded as the beginning of the Deep South, the state remains a deeply conservative part of the country, fervently clinging to its religious and cultural traditions. South Carolinians are kind and open hosts to those who vacation here, eager to share the wealth of their cultural heritage with curious visitors. With many remarkable places to visit like Charleston and Hilton Head, your itinerary here is sure to be diverse and full of scenic attractions.

Tennessee travel guide

4.4
Specialty Museums · Distilleries · Theaters
The Volunteer State
Divided by law, geography, and custom into three major regions, represented by the three stars on state's flag, Tennessee boasts a distinctive musical heritage that includes elements of bluegrass, country-western, and blues. With a countryside as diverse as its people, Tennessee includes landscapes ranging from a mountainous region in the east to the lowlands of the west, with gently rolling hills in the middle. For a well-rounded vacation, you can hike remote mountain trails in the morning and explore the crowded bars of Nashville in the evening. Visit the urban attractions, such as Elvis Presley's former residence in Memphis, but don't miss a chance to spend some time in the Great Smoky Mountains National Park, situated in the eastern part of the state.