15 days in Saint Louis, Chicago & Cincinnati Itinerary

15 days in Saint Louis, Chicago & Cincinnati Itinerary

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Route & dates

15 days in Saint Louis, Chicago & Cincinnati Itinerary

Start: Indianapolis
Drive:  4​h
1
Saint Louis
— 4 nights
Drive:  5​h
2
Chicago
— 6 nights
Drive:  5​h
3
Cincinnati
— 4 nights
Drive:  1​h 30​min
End: Indianapolis

4
nights
Saint Louis

Saint Louis ©
Test the local claim that Saint Louis is second only to Washington, D.C.
You've now added Cardinals Hall of Fame and Museum to your itinerary. Next up on the itinerary: take in panoramic vistas at The Gateway Arch and get to know the resident critters at Saint Louis Zoo.

For other places to visit, ratings, traveler tips, and more tourist information, read Saint Louis trip planner .

Indianapolis to Saint Louis is an approximately 4.5-hour car ride. You can also fly; or take a bus. The time zone changes from Eastern Standard Time to Central Standard Time, which is usually a -1 hour difference. When traveling from Indianapolis in July, plan for a bit warmer days and about the same nights in Saint Louis: temperatures range from 89°F by day to 68°F at night. You will have some time to spend on the 1st (Thu) before leaving for Chicago.

Things to do in Saint Louis

Parks Zoos & Aquariums Museums
Highlights from your plan
Saint Louis Zoo ©
Saint Louis Zoo
The Gateway Arch ©
The Gateway Arch
Cardinals Hall of Fame and Museum ©
Cardinals Hall of Fame and Museum

6
nights
Chicago

Chicago ©
A huge and vibrant city, Chicago is home to top-notch theaters, shops, museums, galleries, and restaurants.
You've now added Adler Planetarium to your itinerary. The adventure continues: get curious at Museum of Science and Industry, meet the residents at Shedd Aquarium, take in the waterfront at Navy Pier, and see the interesting displays at The Field Museum.

To find maps, reviews, traveler tips, and more tourist information, read our Chicago attractions website .

Traveling by flight from Saint Louis to Chicago takes 3.5 hours. Alternatively, you can do a combination of flight and train; or drive. Expect a daytime high around 83°F in August, and nighttime lows around 67°F. You'll have a few hours on the 7th (Wed) to wrap things up before traveling to Cincinnati.

Things to do in Chicago

Museums Childrens Museums Parks
Highlights from your plan
Museum of Science and Industry ©
Museum of Science and Industry
Shedd Aquarium ©
Shedd Aquarium
The Field Museum ©
The Field Museum

4
nights
Cincinnati

Cincinnati ©
Situated on the north bank of the Ohio River, Cincinnati distinguished itself as the only U.S.
Cincinnati Art Museum has been added to your itinerary. There's more to do: examine the collection at Cincinnati Reds Hall of Fame & Museum and get engrossed in the history at National Underground Railroad Freedom Center.

To find maps, ratings, and other tourist information, read our Cincinnati day trip planning website .

Traveling by flight from Chicago to Cincinnati takes 4 hours. Alternatively, you can do a combination of flight, taxi, and bus; or drive. You'll lose 1 hour traveling from Chicago to Cincinnati due to the time zone difference. Expect a daytime high around 84°F in August, and nighttime lows around 63°F. Wrap up your sightseeing on the 11th (Sun) to allow time to drive back home.

Things to do in Cincinnati

Museums Nightlife
Highlights from your plan
Cincinnati Art Museum ©
Cincinnati Art Museum

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