19 days in Southeast Florida Itinerary

Key Largo is known for wildlife, nature, and adventure. Your trip includes some of its best attractions: discover the deep blue sea with a scuba or snorkeling tour, step aboard African Queen Canal Cruise, see the vivid underwater world at Spiegel Grove, and take in the architecture and atmosphere at Key Largo Baptist Church.

For reviews, photos, ratings, and more tourist information, you can read our Key Largo online tour planner.

Sao Paulo, Brazil to Key Largo is an approximately 11.5-hour flight. The time zone difference when traveling from Sao Paulo to Key Largo is minus 2 hours. In May, Key Largo is somewhat warmer than Sao Paulo - with highs of 34°C and lows of 26°C. Finish up your sightseeing early on the 6th (Sat) so you can go by car to West Palm Beach.

Start off your visit on the 7th (Sun): wander the streets of Worth Avenue, relax and rejuvenate at some of the best spas, see the interesting displays at Ragtops Automobile Museum, then look for all kinds of wild species at Loggerhead Marinelife Center, and finally see some colorful creatures with a scuba or snorkeling tour.

For more things to do, reviews, and other tourist information, use the West Palm Beach vacation maker site.

Getting from Key Largo to West Palm Beach by car takes about 2.5 hours. Other options: do a combination of bus and train; or take a bus. May in West Palm Beach sees daily highs of 35°C and lows of 26°C at night. Cap off your sightseeing on the 7th (Sun) early enough to go by car to Miami Beach.

Start off your visit on the 8th (Mon): browse the different shops at Bayside Marketplace, then examine the collection at Vizcaya Museum and Gardens, and then explore the world behind art at Wynwood Walls. On the 9th (Tue), you'll have a packed day of sightseeing: admire the landmark architecture of Art Deco Historic District, then wander the streets of Ocean Drive, then steep yourself in history at Barnacle State Historic Site, and finally buy something for everyone on your list at Lincoln Road.

To see ratings, maps, reviews, and more tourist information, use the Miami Beach travel planner.

Traveling by car from West Palm Beach to Miami Beach takes 1.5 hours. Alternatively, you can drive; or do a combination of train and bus; or take a bus. Expect a daytime high around 36°C in May, and nighttime lows around 27°C. Finish your sightseeing early on the 9th (Tue) to allow enough time to travel to Everglades National Park.

On the 10th (Wed), step off the mainland to explore Long Pine Key, then look for all kinds of wild species at Anhinga Trail, and then explore the activities along Mrazek Pond. Here are some ideas for day two: identify plant and animal life at Shark Valley Visitor Center and then explore the activities along Slough Slog.

To find traveler tips, photos, more things to do, and more tourist information, refer to the Everglades National Park road trip app.

Explore your travel options from Miami Beach to Everglades National Park with the Route module. In May, daytime highs in Everglades National Park are 36°C, while nighttime lows are 29°C. Finish your sightseeing early on the 11th (Thu) so you can fly to Key West.

Key West is known for sightseeing, wildlife, and adventure. Your trip includes some of its best attractions: see the interesting displays at The Ernest Hemingway Home and Museum, take a leisurely stroll along Mallory Square, see the vivid underwater world at Vandenberg Wreck, and head outdoors with Outdoor Activities.

To find traveler tips, more things to do, reviews, and tourist information, refer to the Key West visit planning site.

Traveling by flight from Everglades National Park to Key West takes 2.5 hours. Alternatively, you can take a bus; or take a bus. In May, plan for daily highs up to 34°C, and evening lows to 29°C. Finish your sightseeing early on the 16th (Tue) to allow enough time to drive to Marathon.

Start off your visit on the 17th (Wed): get advice or help at Pigeon Key, then kick back and relax at Bahia Honda State Park, and then stop by Paradise Produce. On the next day, relax and rejuvenate at some of the top local wellness centers, identify plant and animal life at Crane Point Museum & Nature Center, then kick back and relax at Sombrero Beach, and finally look for all kinds of wild species at The Turtle Hospital.

To find reviews, other places to visit, traveler tips, and tourist information, read Marathon day trip app.

You can drive from Key West to Marathon in 1.5 hours. Alternatively, you can take a bus. In May in Marathon, expect temperatures between 36°C during the day and 29°C at night. Wrap up your sightseeing on the 18th (Thu) to allow time to drive to Islamorada.

Start off your visit on the 19th (Fri): take in the exciting artwork at Michelle Nicole Lowe Art Gallery, take an in-depth tour of History of Diving Museum, then cast your line with a fishing tour, and finally sample the tasty concoctions at Florida Keys Brewing Company. On your second day here, step off the mainland to explore Windley Key, soothe aching muscles at some of the top local wellness centers, then sample the tasty concoctions at Islamorada Brewery & Distillery - MM82, and finally tour the pleasant surroundings at Anne's Beach.

For more things to do, where to stay, and tourist information, use the Islamorada day trip site.

Getting from Marathon to Islamorada by car takes about an hour. Other options: take a bus. In May, plan for daily highs up to 36°C, and evening lows to 29°C. On the 21st (Sun), you'll travel back home.