19 days in United States Itinerary

A gateway to Great Smoky Mountains National Park, Knoxville embraces music culture.

You've now added Ijams Nature Center to your itinerary. Start off your visit on the 29th (Sun): identify plant and animal life at Ijams Nature Center, immerse yourself in nature at Seven Islands State Birding Park, and then identify plant and animal life at Forks of the River Wildlife Management Area.

Before you visit Knoxville, use our trip planner to discover what you can do and see there.

Greensboro to Knoxville is an approximately 5-hour car ride. You can also fly; or take a bus. In October, daytime highs in Knoxville are 74°F, while nighttime lows are 51°F. You will leave for Saint Louis on the 31st (Tue).

Test the local claim that Saint Louis is second only to Washington, D.C. in the number of free activities available by spending your holiday exploring the city's central neighborhoods, famous for their restored century-old red-brick buildings.

Start off your visit on the 31st (Tue): wander the streets of Lafayette Square and then sample the tasty concoctions at Anheuser-Busch Brewery. Get ready for a full day of sightseeing on the next day: look for all kinds of wild species at Powder Valley Conservation Nature Center, identify plant and animal life at World Bird Sanctuary, and then wander the streets of Central West End.

For reviews, ratings, maps, and other tourist information, go to the Saint Louis online road trip planner.

Getting from Knoxville to Saint Louis by flight takes about 5.5 hours. Other options: drive; or do a combination of car, shuttle, and bus. The time zone difference moving from Eastern Standard Time (EST) to Central Standard Time (CST) is minus 1 hour. In October, daytime highs in Saint Louis are 72°F, while nighttime lows are 49°F. Finish your sightseeing early on the 2nd (Thu) to allow enough time to fly to Topeka.

Topeka is the capital city of the U.S. state of Kansas and the seat of Shawnee County. On the 2nd (Thu), play a few rounds at Firekeeper Golf Course and then sample the tasty concoctions at Norsemen Brewing Company. On the next day, learn about winemaking at Prairie Fire Winery, then indulge your thirst for a good beer at Happy Basset Brewing Company, and then take in nature's colorful creations at Ted Ensley Gardens.

To see traveler tips, where to stay, reviews, and more tourist information, you can read our Topeka online trip itinerary builder.

Traveling by flight from Saint Louis to Topeka takes 2.5 hours. Alternatively, you can drive; or take a bus. November in Topeka sees daily highs of 57°F and lows of 34°F at night. You will have some time to spend on the 4th (Sat) before leaving for Colorado Springs.

Stunning Garden of the Gods Park scenery, blue skies and the glory of Pikes Peak-America’s Mountain have attracted visitors to Colorado Springs for more than a century.

Eschew the tourist crowds and head to Helen Hunt Falls and North Cheyenne Canon Park. Escape the urban bustle at Colorado Wolf and Wildlife Center and Cheyenne Mountain State Park. Change things up with a short trip to Rock Park in Castle Rock (about 44 minutes away). There's still lots to do: stroll around Garden of the Gods, take in a show at Colorado Springs Fine Arts Center at Colorado College, test your problem-solving skills at popular escape rooms, and surround yourself with nature on Colorado Wolf Adventures.

To see ratings, more things to do, and other tourist information, use the Colorado Springs attractions website.

Traveling by combination of bus and flight from Topeka to Colorado Springs takes 6.5 hours. Alternatively, you can drive; or take a bus. The time zone difference moving from Central Standard Time (CST) to Mountain Standard Time (MST) is minus 1 hour. Traveling from Topeka in November, plan for slightly colder nights in Colorado Springs, with lows around 27°F. Cap off your sightseeing on the 9th (Thu) early enough to catch the flight to Kansas City.

The largest municipality in Missouri, Kansas City has an impressive array of world-class museums, shopping areas, and great places to eat, all of which attract tourism to the area.

Start off your visit on the 9th (Thu): test your team's savvy at popular escape rooms. Here are some ideas for day two: walk around Buffalo Soldier Memorial Park, then sample the fine beverages at Holladay Distillery, and then wander the streets of Country Club Plaza.

To find other places to visit, reviews, where to stay, and tourist information, read our Kansas City online trip itinerary maker.

Getting from Colorado Springs to Kansas City by flight takes about 3 hours. Other options: drive; or do a combination of bus and train. The time zone difference when traveling from Colorado Springs to Kansas City is 1 hour. Traveling from Colorado Springs in November, Kansas City is somewhat warmer at night with lows of 38°F. Finish your sightseeing early on the 11th (Sat) to allow enough time to fly to Louisville.

Kentucky’s largest city, Louisville, is best known as the home of the Kentucky Derby.

On the 12th (Sun), explore the world behind art at 21c Museum Hotel, look for all kinds of wild species at Bernheim Arboretum & Forest, then sample the fine beverages at Four Roses Bourbon - Warehouse and Bottling Facility, and finally boost your wellbeing at a local thermal spa. Get ready for a full day of sightseeing on the next day: explore the fascinating underground world of Louisville Mega Cavern, then brush up on your knowledge of spirits at Copper & Kings American Brandy Distillery, then brush up on your knowledge of spirits at Kentucky Peerless Distilling Co, and finally sample the fine beverages at Jim Beam Urban Stillhouse.

To find where to stay, maps, traveler tips, and more tourist information, read our Louisville trip planning website.

Fly from Kansas City to Louisville in 5 hours. Alternatively, you can drive; or take a bus. Traveling from Kansas City to Louisville, you'll lose 1 hour due to the time zone difference. In November, daytime highs in Louisville are 57°F, while nighttime lows are 37°F. Finish up your sightseeing early on the 14th (Tue) so you can go by car to Lexington.

Known internationally as the "Horse Capital of the World," Lexington boasts a thriving economy resting largely on its thoroughbred racehorse industry.

On the 14th (Tue), identify plant and animal life at Raven Run Nature Sanctuary, indulge in some personalized pampering at some of the best spas, then sample the fine beverages at Bluegrass Distillers, and finally sample the tasty concoctions at West Sixth Brewing. Get ready for a full day of sightseeing on the 15th (Wed): make a trip to Daniel Boone's Grave, savor the flavors at Kentucky River Tours, and then do a tasting at Rising Sons Home Farm Winery.

For where to stay, other places to visit, photos, and other tourist information, refer to the Lexington itinerary planner.

Traveling by car from Louisville to Lexington takes 1.5 hours. Alternatively, you can take a bus. In November, plan for daily highs up to 56°F, and evening lows to 36°F. You will have some time to spend on the 16th (Thu) before leaving for home.