2 days in Southeast Missouri Itinerary

For ratings, photos, reviews, and more tourist information, you can read our New Madrid road trip planning app.

Milan, Italy to New Madrid is an approximately 22.5-hour combination of flight and car. Traveling from Milan to New Madrid, you'll gain 7 hours due to the time zone difference. While traveling from Milan, expect somewhat warmer days and about the same nights in New Madrid, ranging from highs of 26°C to lows of 11°C. On the 30th (Sun), you'll travel to Sainte Genevieve.

Kick off your visit on the 30th (Sun): do a tasting at Crown Valley Winery and then identify plant and animal life at Pickle Springs Natural Area.

To find maps, reviews, and other tourist information, you can read our Sainte Genevieve trip maker website.

You can drive from New Madrid to Sainte Genevieve in 2 hours. In October, plan for daily highs up to 24°C, and evening lows to 11°C. Finish up your sightseeing early on the 30th (Sun) so you can go by car to Poplar Bluff.

To find photos, reviews, maps, and tourist information, you can read our Poplar Bluff online trip itinerary maker.

Traveling by car from Sainte Genevieve to Poplar Bluff takes 2 hours. In October in Poplar Bluff, expect temperatures between 27°C during the day and 11°C at night. On the 30th (Sun), you'll travel back home.