21 days in United States Itinerary

21 days in United States Itinerary

Created using Inspirock United States route planner
Make it your trip
Fly
1
Chicago
— 1 night
Drive
2
Des Moines
— 1 night
Drive
3
Topeka
— 1 night
Drive
4
Kansas City
— 2 nights
Drive
5
Saint Louis
— 1 night
Drive
6
Memphis
— 2 nights
Drive
7
Nashville
— 3 nights
Drive
8
Louisville
— 2 nights
Drive
9
Lexington
— 1 night
Drive
10
Cincinnati
— 1 night
Drive
11
Indianapolis
— 1 night
Drive
12
Chicago
— 4 nights
Fly

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Chicago — 1 night

A huge and vibrant city, Chicago is home to top-notch theaters, shops, museums, galleries, and restaurants.
Kick off your visit on the 6th (Thu): take in the spiritual surroundings of Frank Lloyd Wright's Unity Temple, admire the landmark architecture of Reliance Building, then get a new perspective on nature at Field Museum, and finally test your problem-solving skills at popular escape rooms.

To find out how to plan a trip to Chicago, use our trip itinerary maker.

Rome, Italy to Chicago is an approximately 12.5-hour flight. You'll gain 7 hours traveling from Rome to Chicago due to the time zone difference. Expect little chillier temperatures when traveling from Rome in April; daily highs in Chicago reach 17°C and lows reach 5°C. On the 7th (Fri), you'll have the morning to explore before heading off to Des Moines.
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Museums · Childrens Museums · Fun & Games · Historic Sites
Side Trip

Des Moines — 1 night

Des Moines is the capital and the most populous city in the U.S. state of Iowa. To see reviews and tourist information, you can read our Des Moines visit app.

You can fly from Chicago to Des Moines in 3 hours. Other options are to drive; or take a bus. In April, daily temperatures in Des Moines can reach 19°C, while at night they dip to 5°C. Finish up your sightseeing early on the 8th (Sat) so you can go by car to Topeka.
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Parks · Zoos & Aquariums · Trails · Outdoors

Topeka — 1 night

Topeka is the capital city of the U.S. state of Kansas and the seat of Shawnee County. On the 9th (Sun), contemplate the long history of Brown v. Board of Education National Historic Site, see the interesting displays at Evel Knievel Museum, and then ponder the world of politics at Kansas State Capitol Building.

To see more things to do, reviews, traveler tips, and more tourist information, you can read our Topeka trip maker.

Traveling by car from Des Moines to Topeka takes 4.5 hours. Alternatively, you can drive; or take a bus; or do a combination of bus and train. In April, daytime highs in Topeka are 22°C, while nighttime lows are 6°C. Cap off your sightseeing on the 9th (Sun) early enough to go by car to Kansas City.
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Historic Sites · Museums

Kansas City — 2 nights

The largest municipality in Missouri, Kansas City has an impressive array of world-class museums, shopping areas, and great places to eat, all of which attract tourism to the area.
On the 10th (Mon), steep yourself in history at Union Station, then take an in-depth tour of National WWI Museum and Memorial, then test your problem-solving skills at popular escape rooms, and finally sample the tasty concoctions at Casual Animal Brewing. On the next day, get in on the family fun at LEGOLAND Discovery Center, then admire nature's wide array of creatures at SEA LIFE Kansas City, then explore the world behind art at The Nelson-Atkins Museum of Art, and finally stop by DelBrenna Jewelry In KC.

To find reviews, other places to visit, where to stay, and more tourist information, read our Kansas City trip itinerary planning app.

Traveling by car from Topeka to Kansas City takes an hour. Alternatively, you can take a bus; or take a train. In April, plan for daily highs up to 22°C, and evening lows to 9°C. Finish up your sightseeing early on the 11th (Tue) so you can catch the flight to Saint Louis.
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Museums · Theme Parks · Historic Sites · Zoos & Aquariums

Saint Louis — 1 night

Test the local claim that Saint Louis is second only to Washington, D.C. in the number of free activities available by spending your holiday exploring the city's central neighborhoods, famous for their restored century-old red-brick buildings.
Start off your visit on the 12th (Wed): take in the architecture and atmosphere at Cathedral Basilica of Saint Louis, examine the collection at City Museum, and then take in panoramic vistas at The Gateway Arch.

To find other places to visit, maps, more things to do, and other tourist information, read our Saint Louis online driving holiday planner.

Traveling by flight from Kansas City to Saint Louis takes 2.5 hours. Alternatively, you can drive; or take a bus. April in Saint Louis sees daily highs of 22°C and lows of 9°C at night. Finish your sightseeing early on the 12th (Wed) to allow enough time to fly to Memphis.
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Museums · Historic Sites

Memphis — 2 nights

The largest city on the Mississippi River, Memphis bills itself as both the "Birthplace of Rock" and "Home of the Blues." With such a rich musical heritage, it shouldn't come as a surprise that Elvis Presley chose to live in Memphis during his later years.
Start off your visit on the 13th (Thu): make a trip to Crystal Shrine Grotto, then contemplate the long history of Sun Studio, then contemplate the long history of National Civil Rights Museum - Lorraine Motel, and finally steep yourself in history at The Peabody Ducks.

To see where to stay, ratings, reviews, and other tourist information, read Memphis trip itinerary maker tool.

You can fly from Saint Louis to Memphis in 3.5 hours. Other options are to drive; or take a bus. Traveling from Saint Louis in April, things will get a bit warmer in Memphis: highs are around 26°C and lows about 13°C. Wrap up your sightseeing on the 14th (Fri) to allow time to drive to Nashville.
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Historic Sites · Museums

Nashville — 3 nights

Known as the capital of country music, the thriving city of Nashville combines old-world southern charm with a progressive urban flair.
Nashville is known for nightlife, museums, and historic sites. Your trip includes some of its best attractions: test your team's savvy at popular escape rooms, catch a live performance at Grand Ole Opry, take an in-depth tour of The Johnny Cash Museum & Cafe, and steep yourself in history at Andrew Jackson's Hermitage.

To see more things to do, where to stay, ratings, and more tourist information, refer to the Nashville sightseeing planner.

Drive from Memphis to Nashville in 3.5 hours. Alternatively, you can fly; or take a bus. In April, plan for daily highs up to 26°C, and evening lows to 11°C. Wrap up your sightseeing on the 17th (Mon) early enough to drive to Louisville.
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Museums · Historic Sites · Breweries & Distilleries · Neighborhoods
Side Trip

Louisville — 2 nights

Kentucky’s largest city, Louisville, is best known as the home of the Kentucky Derby.
On the 18th (Tue), brush up on your knowledge of spirits at Kentucky Artisan Distillery, indulge your taste buds at Food & Drink, and then explore the fascinating underground world of Louisville Mega Cavern. Keep things going the next day: stroll the grounds of Zachary Taylor National Cemetery, then examine the collection at Kentucky Derby Museum, then examine the collection at Louisville Slugger Museum & Factory, and finally brush up on your knowledge of spirits at Copper & Kings American Brandy Distillery.

For ratings, traveler tips, where to stay, and more tourist information, read our Louisville road trip website.

Getting from Nashville to Louisville by car takes about 3 hours. Other options: take a bus; or fly. The time zone difference moving from Central Standard Time to Eastern Standard Time is 1 hour. April in Louisville sees daily highs of 24°C and lows of 10°C at night. Wrap up your sightseeing on the 19th (Wed) early enough to drive to Lexington.
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Breweries & Distilleries · Museums · Tours · Parks
Side Trip

Lexington — 1 night

Known internationally as the "Horse Capital of the World," Lexington boasts a thriving economy resting largely on its thoroughbred racehorse industry.
Kick off your visit on the 20th (Thu): experience rural life at Taylor Made Farm, then experience rural life at Mill Ridge Farm, then brush up on your knowledge of spirits at Bluegrass Distillers, and finally try your luck at Keeneland.

To find reviews, ratings, maps, and more tourist information, read our Lexington trip itinerary builder website.

Traveling by car from Louisville to Lexington takes 1.5 hours. Alternatively, you can take a bus. In April, daytime highs in Lexington are 23°C, while nighttime lows are 9°C. Cap off your sightseeing on the 20th (Thu) early enough to go by car to Cincinnati.
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Casinos · Fun & Games · Breweries & Distilleries
Side Trip

Cincinnati — 1 night

Situated on the north bank of the Ohio River, Cincinnati distinguished itself as the only U.S. city that left a favorable impression on one of its most famous 19th-century visitors, English author Charles Dickens.
Start off your visit on the 21st (Fri): get to know the resident critters at Cincinnati Zoo & Botanical Garden, learn more about the world around you at Creation Museum, and then learn the secrets of beer at a beer tour and tasting.

For where to stay, ratings, more things to do, and more tourist information, go to the Cincinnati trip planner.

Traveling by car from Lexington to Cincinnati takes 1.5 hours. Alternatively, you can take a bus. In April, plan for daily highs up to 22°C, and evening lows to 7°C. Wrap up your sightseeing on the 21st (Fri) early enough to drive to Indianapolis.
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Tours · Breweries & Distilleries · Museums · Zoos & Aquariums
Side Trip

Indianapolis — 1 night

Indiana's capital and most populous city, Indianapolis is best known for its racecar events and impressive museums, and as the hometown of Kurt Vonnegut.
For maps, ratings, more things to do, and other tourist information, refer to the Indianapolis online itinerary maker.

Traveling by car from Cincinnati to Indianapolis takes 2 hours. Alternatively, you can take a bus. In April in Indianapolis, expect temperatures between 20°C during the day and 7°C at night. On the 22nd (Sat), you'll travel to Chicago.
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Parks · Museums · Nightlife · Fun & Games

Chicago — 4 nights

Enjoy Chicago some more: explore the world behind art at The Art Institute of Chicago, stroll around Millennium Park, admire the striking features of Skydeck Chicago - Willis Tower, and wander the streets of The Magnificent Mile.

For traveler tips, maps, more things to do, and tourist information, go to the Chicago trip planner.

Traveling by flight from Indianapolis to Chicago takes 2.5 hours. Alternatively, you can drive; or take a bus. Due to the time zone difference, you'll gain 1 hour traveling from Indianapolis to Chicago. When traveling from Indianapolis in April, plan for little chillier days and about the same nights in Chicago: temperatures range from 17°C by day to 5°C at night. Wrap up your sightseeing on the 26th (Wed) early enough to fly back home.
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Parks · Zoos & Aquariums · Museums · Shopping
Side Trip

United States travel guide

4.5
Specialty Museums · Historic Sites · Nightlife
More than the country of car-packed streets seen in TV shows and movies, the United States of America is a complex and diverse home to over 300 million people living in a wide range of landscapes and climates. From its big-city skyscrapers to its sprawling natural parks, the country's ''melting pot'' combines many ethnic groups that share a strong sense of national identity despite their cultural differences. A country of road trips and big blue skies, the United States harbors orderly cities filled with restaurants, parks, museums, and innumerable sightseeing opportunities, as well as pristine natural areas perfect for a holiday in the great outdoors. To see as much as you can of this diverse land quickly, drive over some of the more than 6 million km (4 million mi) of highways leading through deserts, mountain peaks, fertile fields, and giant urban centers.
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