22 days in Florida Itinerary

22 days in Florida Itinerary

Created using Inspirock Florida travel planner

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Route & dates

22 days in Florida Itinerary

Start: Saint Louis
Fly:  4​h 45​min
1
Orlando
— 4 nights
Fly + Drive:  5​h 15​min
2
St. George Island
— 2 nights
+2
Drive + Fly + Drive:  5​h 15​min
3
Miami Beach
— 3 nights
Drive:  1​h 30​min
4
Key Largo
— 3 nights
Drive:  45​min
5
Islamorada
— 3 nights
Drive:  45​min
6
Marathon
— 3 nights
bus:  1​h 15​min
7
Key West
— 3 nights
Fly:  6​h 30​min
End: Saint Louis

4
nights
Orlando

Orlando ©
For most people, any mention of Orlando immediately conjures up images of sprawling theme parks filled with characters plucked right out of popular animated movies.
Orlando is known for theme parks, nightlife, fun & games, shopping, and museums. Your plan includes some of its best attractions: find something for the whole family at Walt Disney World Resort, explore the world behind art at Charles Hosmer Morse Museum of American Art, get your game on at Nomadic, and make an unforgettable trip to Happily Ever After Fireworks.

To find traveler tips, photos, and other tourist information, use the Orlando day trip app .

Saint Louis to Orlando is an approximately 5-hour flight. You can also drive; or take a bus. You'll lose 1 hour traveling from Saint Louis to Orlando due to the time zone difference. Traveling from Saint Louis in December, expect Orlando to be warmer, temps between 77°F and 59°F. Finish up your sightseeing early on the 20th (Fri) so you can travel to St. George Island.

Things to do in Orlando

Theme Parks Fun & Games Museums

Side Trip

Charles Hosmer Morse Museum of American Art
Highlights from your plan
Walt Disney World Resort ©
Walt Disney World Resort
Universal Orlando Resort ©
Universal Orlando Resort
Universal's Islands of Adventure ©
Universal's Islands of Adventure

2
nights
St. George Island

St. George Island ©
Your day-by-day itinerary now includes Saint George Island State Park. On the 21st (Sat), don't miss a visit to Bob Sikes Cut, then look for gifts at Sometimes It's Hotter, then admire the majestic nature at Saint George Island State Park, and finally get a taste of the local shopping with Sea Oats Art Gallery. On the 22nd (Sun), you'll have a packed day of sightseeing: identify plant and animal life at Wildlife Areas and then identify plant and animal life at Apalachicola National Estuarine Research Reserve.

Plan my trip to St. George Island with suggested itineraries provided by Inspirock.

The Route module can help you plan travel from Orlando to St. George Island. Prepare for little chillier weather when traveling from Orlando in December: high temperatures in St. George Island hover around 70°F and lows are around 52°F. Finish your sightseeing early on the 22nd (Sun) so you can travel to Miami Beach.

Things to do in St. George Island

Wildlife Parks Outdoors

Side Trip

Apalachicola National Estuarine Research Reserve
Highlights from your plan
Sometimes It's Hotter ©
Sometimes It's Hotter
Sea Oats Art Gallery ©
Sea Oats Art Gallery

3
nights
Miami Beach

Miami Beach ©
Separated by water from the neighboring city of Miami, Miami Beach sits on a barrier island between Biscayne Bay and the Atlantic Ocean.
Get out of town with these interesting Miami Beach side-trips: Fairchild Tropical Botanic Garden (in Coral Gables) and Everglades National Park (Shark Valley Visitor Center & Gumbo Limbo Trail). And it doesn't end there: kick back and relax at South Beach, appreciate the extensive heritage of Art Deco Historic District, examine the collection at Lock & Load Museum, and take in the architecture and atmosphere at St Patrick Catholic Church.

For more things to do, other places to visit, traveler tips, and other tourist information, go to the Miami Beach trip planner .

Explore your travel options from St. George Island to Miami Beach with the Route module. Expect a bit warmer temperatures when traveling from St. George Island in December; daily highs in Miami Beach reach 81°F and lows reach 68°F. Finish your sightseeing early on the 25th (Wed) so you can drive to Key Largo.

Things to do in Miami Beach

Parks Outdoors Trails

Side Trips

Miami, Coral Gables, Everglades National Park
Highlights from your plan
Lock & Load Museum ©
Lock & Load Museum
Shark Valley Visitor Center ©
Shark Valley Visitor Center
Fairchild Tropical Botanic Garden ©
Fairchild Tropical Botanic Garden

3
nights
Key Largo

Key Largo ©
The northernmost island of the Florida Keys, Key Largo provides stunning scenery, a number of watersports opportunities, and plenty of areas to relax on vacation.
When in Key Largo, make a side trip to see Anhinga Trail in Everglades National Park, approximately 48 minutes away. There's much more to do: look for all kinds of wild species at Florida Keys Wild Bird Rehabilitation Center, observe the fascinating underwater world at Island Dolphin Care, see some colorful creatures with a scuba or snorkeling tour, and explore the landscape on two wheels at Florida Keys Visitor Center.

For more things to do, reviews, other places to visit, and tourist information, read Key Largo online trip itinerary builder .

Getting from Miami Beach to Key Largo by car takes about 1.5 hours. Other options: take a bus. In December in Key Largo, expect temperatures between 79°F during the day and 66°F at night. Wrap up your sightseeing on the 28th (Sat) early enough to drive to Islamorada.

Things to do in Key Largo

Parks Wildlife Outdoors

Side Trip

Anhinga Trail
Highlights from your plan
Island Dolphin Care ©
Island Dolphin Care
Anhinga Trail ©
Anhinga Trail

3
nights
Islamorada

Islamorada, long recognized as one of the world's top spots for sport fishing, encompasses six islands in the Florida Keys.
Venture out of the city with trips to Everglades National Park (99 Mile Wilderness Waterway & Nine Mile Pond Canoe Trail). There's lots more to do: cast your line with a fishing tour, get outside with A Lil' Tail Charters, look for gifts at Bella Sol Fragrance Bar and Gifts, and admire the majestic nature at Lignumvitae Key Botanical State Park.

For traveler tips, photos, more things to do, and tourist information, refer to the Islamorada tour itinerary planner.

Traveling by car from Key Largo to Islamorada takes an hour. Alternatively, you can do a combination of taxi and bus. Expect a daytime high around 80°F in December, and nighttime lows around 71°F. Cap off your sightseeing on the 31st (Tue) early enough to go by car to Marathon.

Things to do in Islamorada

Outdoors Wildlife Parks

Side Trip

Everglades National Park
Highlights from your plan
Fishing Charters & Tours
99 Mile Wilderness Waterway ©
99 Mile Wilderness Waterway
Nine Mile Pond Canoe Trail ©
Nine Mile Pond Canoe Trail

3
nights
Marathon

Marathon ©
A tiny city just 16 km (10 mi) long, Marathon is spread across several islands in the middle of the Florida Keys.
Step out of Marathon with an excursion to National Key Deer Refuge in Big Pine Key--about 34 minutes away. There's still lots to do: kick back and relax at Bahia Honda State Park, stroll through Sombrero Beach, look for all kinds of wild species at Marathon Garden Club, and relax and rejuvenate at some of the top local wellness centers.

To see traveler tips, reviews, and tourist information, read Marathon trip itinerary planner.

Traveling by car from Islamorada to Marathon takes an hour. Alternatively, you can take a bus. In December in Marathon, expect temperatures between 80°F during the day and 71°F at night. Wrap up your sightseeing on the 3rd (Fri) early enough to take a bus to Key West.

Things to do in Marathon

Parks Wildlife Outdoors

Side Trip

Big Pine Key
Highlights from your plan
Bahia Honda State Park ©
Bahia Honda State Park
National Key Deer Refuge ©
National Key Deer Refuge
Gemini Dream Charters ©
Gemini Dream Charters

3
nights
Key West

Key West ©
Located just 140 km (90 mi) from Cuba, Key West is an island only about 6.4 km (4 mi) long and 1.6 km (1 mi) wide.
Key West is known for wildlife, museums, adventure, nightlife, and historic sites. Your plan includes some of its best attractions: examine the collection at The Ernest Hemingway Home and Museum, steep yourself in history at Audubon House & Tropical Gardens, walk around Mallory Square, and identify plant and animal life at Key West Butterfly & Nature Conservatory.

To find reviews, more things to do, photos, and more tourist information, read Key West travel route planning tool .

Take a bus from Marathon to Key West in 1.5 hours. Alternatively, you can drive. In January in Key West, expect temperatures between 76°F during the day and 66°F at night. Wrap up your sightseeing on the 6th (Mon) to allow time to travel back home.

Things to do in Key West

Wildlife Outdoors Tours
Highlights from your plan
The Ernest Hemingway Home and Museum ©
Scuba & Snorkeling

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