22 days in Maine & South Carolina Itinerary

22 days in Maine & South Carolina Itinerary

Created using Inspirock United States trip planner

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Route & dates

Start: Portland
Fly + Drive:  10 h 30 min
1
Boothbay
— 3 nights
Drive:  1 h 45 min
2
Ogunquit
— 2 nights
Drive:  4 h
3
Bar Harbor, Mount Desert Island
— 3 nights
Fly:  6 h 45 min
4
Myrtle Beach
— 3 nights
Drive:  2 h 15 min
5
Charleston
— 4 nights
Drive:  2 h 15 min
6
Hilton Head
— 2 nights
Drive:  3 h
7
Columbia
— 2 nights
Bus:  1 h 30 min
8
Greenville
— 2 nights
Taxi + Fly:  8 h 30 min
End: Portland

3
nights
Boothbay

Boothbay ©
Boothbay is a town in Lincoln County, Maine, United States. Change things up with these side-trips from Boothbay: Mount Battie (in Camden), Farnsworth Art Museum (in Rockland) and Cellardoor Winery (in Lincolnville). There's lots more to do: enjoy the sea views from Pemaquid Point Lighthouse, identify plant and animal life at Boothbay Region Land Trust, stop by Dirty Bird Pottery, and step off the mainland to explore Cabbage Island.

For where to stay, photos, and more tourist information, refer to the Boothbay trip itinerary builder site.

Portland to Boothbay is an approximately 10.5- hour combination of flight and car. You can also drive. The time zone changes from Pacific Standard Time to Eastern Standard Time, which is usually a 3 hour difference. In September, daytime highs in Boothbay are 73°F, while nighttime lows are 51°F. Finish your sightseeing early on the 10th (Thu) to allow enough time to drive to Ogunquit.

Things to do in Boothbay

Parks Historic Sites Nature

Side Trips

Boothbay Harbor, Mount Battie, Finnish Church and Heritage House, Farnsworth Art Museum, Owls Head Transportation Museum
Highlights from your plan
Mount Battie ©
Mount Battie
Pemaquid Point Lighthouse ©
Pemaquid Point Lighthouse
Boothbay Region Land Trust ©
Boothbay Region Land Trust

2
nights
Ogunquit

Ogunquit ©
Ogunquit means "beautiful place by the sea" in the language of the Native Americans who inhabited the region long ago, and this remains an accurate description of this holiday destination today.
On the 11th (Fri), explore the world behind art at George Marshall Store Gallery, enjoy the sea views from Nubble Lighthouse, then take in the dramatic natural features at Perkins Cove, and finally appreciate the extensive heritage of Marginal Way Walkway. Get ready for a full day of sightseeing on the 12th (Sat): pause for some serene contemplation at St. Ann's Episcopal Church, take a tour by water with Boat Tours & Water Sports, then look for gifts at Mainely Murders Bookstore, and finally stroll through Ogunquit Beach.

To see traveler tips, other places to visit, ratings, and other tourist information, refer to the Ogunquit online trip builder.

Drive from Boothbay to Ogunquit in 2 hours. In September, daytime highs in Ogunquit are 74°F, while nighttime lows are 48°F. Finish your sightseeing early on the 12th (Sat) so you can drive to Bar Harbor.

Things to do in Ogunquit

Historic Sites Parks Outdoors

Side Trips

Kennebunkport, York, Mainely Murders Bookstore
Highlights from your plan
Marginal Way Walkway ©
Marginal Way Walkway
Perkins Cove ©
Perkins Cove
Nubble Lighthouse ©
Nubble Lighthouse

3
nights
Bar Harbor, Mount Desert Island

Bar Harbor ©
Bar Harbor is a town on Mount Desert Island in Hancock County, Maine, United States. Explore Bar Harbor's surroundings by going to US Bells (in Prospect Harbor) and Schoodic Point (in Winter Harbor). There's still lots to do: examine the collection at The Seal Cove Auto Museum, explore the landscape on two wheels at Carriage Roads, take an in-depth tour of Somesville Historical Museum and Gardens, and go for a walk through Compass Harbor Trail.

For photos, more things to do, reviews, and other tourist information, use the Bar Harbor online trip itinerary maker.

Drive from Ogunquit to Bar Harbor in 4 hours. Alternatively, you can do a combination of bus and flight; or do a combination of taxi, train, and bus. In September, daily temperatures in Bar Harbor can reach 70°F, while at night they dip to 52°F. Cap off your sightseeing on the 15th (Tue) early enough to travel to Myrtle Beach.

Things to do in Bar Harbor

Parks Outdoors Trails

Side Trips

Acadia National Park, Schoodic Point, Somesville Historical Museum and Gardens, The Seal Cove Auto Museum, US Bells
Highlights from your plan
The Seal Cove Auto Museum ©
The Seal Cove Auto Museum
Boat Tours & Water Sports
Cadillac Mountain ©
Cadillac Mountain

3
nights
Myrtle Beach

Myrtle Beach ©
Myrtle Beach is a coastal city on the east coast of the United States in Horry County, South Carolina. Venture out of the city with trips to Boat Tours & Water Sports (in North Myrtle Beach) and Brookgreen Gardens (in Murrells Inlet). The adventure continues: get up close and personal with brilliant marine life at Ripley's Aquarium of Myrtle Beach, have some family-friendly fun at Backstage Mirror Maze, kick back and relax at Myrtle Beach, and learn about all things military at Warbird Park.

To see maps, traveler tips, reviews, and tourist information, read our Myrtle Beach trip itinerary builder app.

Traveling by flight from Bar Harbor to Myrtle Beach takes 7 hours. Alternatively, you can do a combination of shuttle, bus, and flight; or drive. In September, Myrtle Beach is a bit warmer than Bar Harbor - with highs of 83°F and lows of 69°F. Finish your sightseeing early on the 18th (Fri) so you can drive to Charleston.

Things to do in Myrtle Beach

Parks Outdoors Museums

Side Trips

Boat Tours & Water Sports, Brookgreen Gardens
Highlights from your plan
Myrtle Beach Pinball Museum ©
Myrtle Beach Pinball Museum
Ripley's Aquarium of Myrtle Beach ©
Ripley's Aquarium of Myrtle Beach
Myrtle Beach SkyWheel ©
Myrtle Beach SkyWheel

4
nights
Charleston

Many visitors describe their Charleston holiday as a warm embrace by an old, dear friend--who lived about 200 years ago.
Charleston is known for parks, historic sites, and shopping. Your plan includes some of its best attractions: steep yourself in history at Fort Sumter National Monument, walk around Joe Riley Waterfront Park, take in nature's colorful creations at Magnolia Plantation & Gardens, and see majestic marine mammals with a dolphin and whale watching tour.

To find out how to plan a trip to Charleston, use our trip itinerary maker.

Getting from Myrtle Beach to Charleston by car takes about 2.5 hours. Other options: take a bus. In September, daily temperatures in Charleston can reach 84°F, while at night they dip to 70°F. Finish up your sightseeing early on the 22nd (Tue) so you can go by car to Hilton Head.

Things to do in Charleston

Parks Historic Sites Museums

Side Trips

Angel Oak Tree, Edgar Allan Poe LIbrary, Warren Lasch Conservation Center - H.L. Hunley Submarine
Highlights from your plan
Horse-Drawn Carriage Tours
Fort Sumter National Monument ©
Fort Sumter National Monument
Magnolia Plantation & Gardens ©
Magnolia Plantation & Gardens

2
nights
Hilton Head

Hilton Head ©
A Hilton Head vacation may be heaven for a golfer, but the area also offers all kinds of other options for sports fans.
On the 23rd (Wed), hike along Hilton Head Island Bike Trails, look for all kinds of wild species at Wildlife Areas, and then kick back and relax at Coligny Beach. Keep things going the next day: get a taste of the local shopping with The Silver Garden Gallery, go for a charming ride with a horse-drawn carriage tour, see the interesting displays at Pat Conroy Literary Center, then stroll around Henry C. Chambers Waterfront Park, and finally sample the fine beverages at Hilton Head Distillery.

For traveler tips, photos, maps, and more tourist information, you can read our Hilton Head trip planner.

Traveling by car from Charleston to Hilton Head takes 2.5 hours. Alternatively, you can take a bus. In September in Hilton Head, expect temperatures between 84°F during the day and 71°F at night. Wrap up your sightseeing on the 24th (Thu) to allow time to drive to Columbia.

Things to do in Hilton Head

Outdoors Parks Tours

Side Trip

Beaufort
Highlights from your plan
Pat Conroy Literary Center ©
Pat Conroy Literary Center
Dolphin & Whale Watching
Hilton Head Island Bike Trails ©
Hilton Head Island Bike Trails

2
nights
Columbia

Columbia ©
A compact capital with stately southern history, Columbia serves as a symbol of the south.
Kick off your visit on the 25th (Fri): learn about wildlife with up-close encounters at Riverbanks Zoo and Botanical Garden, then get your game on at The Final Door Escape Room Columbia, and then have some family-friendly fun at Craft Axe Throwing- Columbia. Keep things going the next day: browse the eclectic array of goods at Soda City, ponder the world of politics at South Carolina State House, and then indulge in some culinary diversions at a local gastronomic tour.

To see traveler tips, photos, reviews, and other tourist information, read Columbia day trip site.

Traveling by car from Hilton Head to Columbia takes 3 hours. Alternatively, you can do a combination of taxi and train; or take a bus. In September in Columbia, expect temperatures between 87°F during the day and 68°F at night. Finish up your sightseeing early on the 26th (Sat) so you can catch the bus to Greenville.

Things to do in Columbia

Parks Zoos & Aquariums Fun & Games
Highlights from your plan
The Final Door Escape Room Columbia ©
The Final Door Escape Room Columbia
Riverbanks Zoo and Botanical Garden ©
Riverbanks Zoo and Botanical Garden
Craft Axe Throwing- Columbia ©
Craft Axe Throwing- Columbia

2
nights
Greenville

Greenville ©
The largest city in "upstate" South Carolina, Greenville has grown around the natural wonders of waterfalls located in the downtown area.
Start off your visit on the 27th (Sun): walk around Falls Park on the Reedy, take in the views from Liberty Bridge, then have some family-friendly fun at Craft Axe Throwing- Greenville, and finally don't miss a visit to Noma Square. Here are some ideas for day two: explore the landscape on two wheels at GHS Swamp Rabbit Trail, stroll around Cancer Survivors Park, then stop by M.Judson Booksellers & Storytellers, then appreciate the history behind Joel Roberts Poinsett Statue, and finally brush up on your knowledge of spirits at Dark Corner Distillery.

For photos, reviews, traveler tips, and more tourist information, you can read our Greenville trip planner.

Traveling by bus from Columbia to Greenville takes 1.5 hours. Alternatively, you can drive. In September, daytime highs in Greenville are 83°F, while nighttime lows are 66°F. Wrap up your sightseeing on the 28th (Mon) early enough to travel back home.

Things to do in Greenville

Parks Trails Outdoors
Highlights from your plan
Falls Park on the Reedy ©
Falls Park on the Reedy
Craft Axe Throwing- Greenville ©
Craft Axe Throwing- Greenville
Liberty Bridge ©
Liberty Bridge

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