22 days in Missouri Itinerary

Your inner history buff will appreciate Laura Ingalls Wilder Historic Home and Museum and Pea Ridge National Military Park. Get outdoors at Buffalo National River and Golf at Top of the Rock. Change things up with these side-trips from Branson: Cosmic Cavern (in Berryville) and Mildred B. Cooper Memorial Chapel (in Bella Vista). And it doesn't end there: Head underground at Talking Rocks Cavern, contemplate the waterfront views at Lake Taneycomo, trek along Lost Canyon Nature Trail and Cave, and kick your exploration up a notch at some of the top local zipline courses and adventure parks.

To see ratings, where to stay, reviews, and more tourist information, read Branson trip planner.

Chicago to Branson is an approximately 3-hour flight. You can also drive; or do a combination of train, bus, and taxi. In September, daily temperatures in Branson can reach 82°F, while at night they dip to 60°F. Wrap up your sightseeing on the 11th (Mon) to allow time to drive to Camdenton.

On the 11th (Mon), stop by Grandma's Candy Kitchen.

To see more things to do, traveler tips, photos, and other tourist information, read our Camdenton trip maker.

You can drive from Branson to Camdenton in 2 hours. In September, daytime highs in Camdenton are 79°F, while nighttime lows are 58°F. On the 12th (Tue), wrap the sightseeing up by early afternoon so you can drive to Jefferson City.

Start off your visit on the 12th (Tue): admire the landmark architecture of America's National Churchill Museum, then identify plant and animal life at Runge Conservation Nature Center, then get a sense of history and politics at Governor's Mansion, and finally steep yourself in history at Missouri State Penitentiary.

To see maps, reviews, photos, and tourist information, go to the Jefferson City visit site.

Traveling by car from Camdenton to Jefferson City takes an hour. In September, daily temperatures in Jefferson City can reach 82°F, while at night they dip to 59°F. Finish up your sightseeing early on the 13th (Wed) so you can go by car to Leasburg.

Get in touch with nature at Meramec Caverns and Onondaga Cave State Park. You'll discover tucked-away gems like Meramec State Park and Onondaga Cave. You'll find plenty of places to visit near Leasburg: Dillard Mill State Historic Site (in Davisville) and Montauk State Park (in Salem).

For ratings, maps, more things to do, and more tourist information, you can read our Leasburg vacation planner.

Traveling by car from Jefferson City to Leasburg takes 1.5 hours. September in Leasburg sees daily highs of 81°F and lows of 59°F at night. Finish your sightseeing early on the 16th (Sat) so you can drive to Middle Brook.

Eschew the tourist crowds and head to Bollinger Mill State Historic Site and Arcadia Valley. Visiting Sam A Baker State Park and St. Joe State Park will get you outdoors. Change things up with these side-trips from Middle Brook: Sainte Genevieve (Felix Valle House State Historic Site & Sainte Genevieve Winery) and St. Francois State Park (in Bonne Terre). Spend the 17th (Sun) exploring nature at Ozark National Scenic Riverways.

To find more things to do, where to stay, ratings, and other tourist information, you can read our Middle Brook visit planner.

You can drive from Leasburg to Middle Brook in 1.5 hours. In September, daily temperatures in Middle Brook can reach 81°F, while at night they dip to 58°F. Wrap up your sightseeing on the 20th (Wed) early enough to drive to Saint Louis.

Escape the urban bustle at Gateway Arch National Park and The Sophia M. Sachs Butterfly House. You'll explore the less-touristy side of things at Ulysses S. Grant National Historical Site and World Bird Sanctuary. Venture out of the city with trips to Castlewood State Park (in Ballwin), The Historic Daniel Boone Home at Lindenwood Park (in Defiance) and Eckert's Belleville Farm (in Belleville). And it doesn't end there: take an in-depth tour of The National Museum of Transportation, learn about winemaking at Montelle Winery, and examine the collection at Cardinals Hall of Fame and Museum.

Plan a trip to Saint Louis easily and quickly by telling Inspirock to suggest an itinerary.

Traveling by car from Middle Brook to Saint Louis takes 1.5 hours. In September, plan for daily highs up to 84°F, and evening lows to 59°F. Finish your sightseeing early on the 23rd (Sat) to allow enough time to drive to Hannibal.

Kick off your visit on the 23rd (Sat): steep yourself in history at Becky Thatcher's House, steep yourself in history at Mark Twain Birthplace State Historic Site, and then explore the activities along Mark Twain State Park. Get ready for a full day of sightseeing on the 24th (Sun): examine the collection at Big River Train Town, then visit a coastal fixture at Mark Twain Memorial Lighthouse, then contemplate the long history of Mark Twain Boyhood Home, and finally get great views at Lovers Leap.

Plan a trip to Hannibal easily and quickly by telling Inspirock to suggest an itinerary.

Traveling by car from Saint Louis to Hannibal takes 2 hours. Alternatively, you can take a shuttle; or fly. In September, daily temperatures in Hannibal can reach 83°F, while at night they dip to 59°F. Finish your sightseeing early on the 25th (Mon) to allow enough time to fly to Kansas City.

Step out of the city life by going to Knob Noster State Park and Weston Bend State Park. Eschew the tourist crowds and head to Loose Park and Glore Psychiatric Museum. Change things up with a short trip to Pony Express Museum in Saint Joseph (about 1h 5 min away).

To see more things to do, other places to visit, ratings, and other tourist information, refer to the Kansas City online trip itinerary builder.

You can fly from Hannibal to Kansas City in 2.5 hours. Alternatively, you can drive; or take a bus. In September, plan for daily highs up to 83°F, and evening lows to 64°F. Wrap up your sightseeing by early afternoon on the 27th (Wed) to allow time for the flight back home.