22 days in South Carolina Itinerary

22 days in South Carolina Itinerary

Created using Inspirock South Carolina journey planner

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Route & dates

22 days in South Carolina Itinerary

Start: Erie
+2
Bus + Fly + Taxi:  5 h 45 min
1
Greenville
— 3 nights
Drive:  4 h 45 min
2
Hilton Head
— 4 nights
Drive:  1 h
3
Beaufort
— 4 nights
Drive:  1 h 30 min
4
Charleston
— 6 nights
Drive:  2 h 15 min
5
Myrtle Beach
— 4 nights
+3
Fly + Subway + Foot + Train:  5 h 15 min
End: Erie

3
nights
Greenville

Greenville ©
The largest city in "upstate" South Carolina, Greenville has grown around the natural wonders of waterfalls located in the downtown area.
Change things up with these side-trips from Greenville: Southern Hills Lavender (in Greer) and Columbia (Escape Plan Columbia & Riverbanks Zoo and Botanical Garden). There's still lots to do: admire the sheer force of Falls Park on the Reedy, sample the fine beverages at Dark Corner Distillery, stroll around Cancer Survivors Park, and take in the views from Liberty Bridge.

To see where to stay, maps, ratings, and more tourist information, read our Greenville trip itinerary builder tool.

Erie to Greenville is an approximately 6-hour combination of flight and taxi. You can also drive; or take a bus. When traveling from Erie in March, plan for much warmer days and a bit warmer nights in Greenville: temperatures range from 64°F by day to 43°F at night. Wrap up your sightseeing on the 6th (Fri) to allow time to drive to Hilton Head.

Things to do in Greenville

Parks Outdoors Zoos & Aquariums

Side Trips

Columbia, Southern Hills Lavender
Highlights from your plan
Falls Park on the Reedy ©
Falls Park on the Reedy
Escape Plan Columbia ©
Escape Plan Columbia
Dark Corner Distillery ©
Dark Corner Distillery

4
nights
Hilton Head

Hilton Head ©
A Hilton Head vacation may be heaven for a golfer, but the area also offers all kinds of other options for sports fans.
Hilton Head is known for wildlife, beaches, and adventure. Your plan includes some of its best attractions: get a new perspective on things with Boat Tours & Water Sports, indulge in some personalized pampering at some of the best spas, sample the fine beverages at Hilton Head Distillery, and identify plant and animal life at Sea Pines Forest Preserve.

To see other places to visit, where to stay, traveler tips, and more tourist information, refer to the Hilton Head trip itinerary planner.

Traveling by car from Greenville to Hilton Head takes 5 hours. Alternatively, you can do a combination of taxi and flight; or do a combination of bus and flight. Traveling from Greenville in March, plan for a bit warmer nights in Hilton Head, with lows around 50°F. Finish up your sightseeing early on the 10th (Tue) so you can go by car to Beaufort.

Things to do in Hilton Head

Parks Outdoors Wildlife

Side Trip

The Church of the Cross
Highlights from your plan
Hilton Head Island Bike Trails ©
Hilton Head Island Bike Trails
Dolphin & Whale Watching
Coligny Beach ©
Coligny Beach

4
nights
Beaufort

Beaufort ©
Beaufort is a city in and the county seat of Beaufort County, South Carolina, United States. Change things up with these side-trips from Beaufort: South Carolina Artisans Center (in Walterboro), Eden Wind Farm (in Johns Island) and Morris Center for Lowcountry Heritage (in Ridgeland). There's much more to do: stroll around Henry C. Chambers Waterfront Park, see the interesting displays at Pat Conroy Literary Center, admire the majestic nature at Hunting Island State Park, and steep yourself in history at Charlesfort / Santa Elena Monument.

To see other places to visit, more things to do, where to stay, and other tourist information, go to the Beaufort trip website.

You can drive from Hilton Head to Beaufort in an hour. Another option is to take a bus. In March, daytime highs in Beaufort are 67°F, while nighttime lows are 48°F. Wrap up your sightseeing on the 14th (Sat) early enough to drive to Charleston.

Things to do in Beaufort

Historic Sites Parks Nature

Side Trips

South Carolina Artisans Center, Morris Center for Lowcountry Heritage, Eden Wind Farm
Highlights from your plan
Pat Conroy Literary Center ©
Pat Conroy Literary Center
Horse-Drawn Carriage Tours
Henry C. Chambers Waterfront Park ©
Henry C. Chambers Waterfront Park

6
nights
Charleston

Charleston ©
Many visitors describe their Charleston holiday as a warm embrace by an old, dear friend--who lived about 200 years ago.
Charleston is known for parks, historic sites, and shopping. Your plan includes some of its best attractions: admire the natural beauty at Magnolia Plantation & Gardens, go on a hair-raising tour with a ghost and vampire tour, walk around Joe Riley Waterfront Park, and get engrossed in the history at Fort Sumter National Monument.

To find more things to do, maps, photos, and other tourist information, use the Charleston trip itinerary builder.

Traveling by car from Beaufort to Charleston takes 1.5 hours. Alternatively, you can take a bus. March in Charleston sees daily highs of 66°F and lows of 47°F at night. Wrap up your sightseeing on the 20th (Fri) to allow time to drive to Myrtle Beach.

Things to do in Charleston

Parks Historic Sites Museums

Side Trip

Patriots Point
Highlights from your plan
Magnolia Plantation & Gardens ©
Magnolia Plantation & Gardens
Middleton Place ©
Middleton Place
Fort Sumter National Monument ©
Fort Sumter National Monument

4
nights
Myrtle Beach

Myrtle Beach ©
Myrtle Beach is a coastal city on the east coast of the United States in Horry County, South Carolina. Get out of town with these interesting Myrtle Beach side-trips: Murrells Inlet (Brookgreen Gardens & Huntington Beach State Park) and Kaminski House Museum (in Georgetown). Next up on the itinerary: get up close and personal with brilliant marine life at Ripley's Aquarium of Myrtle Beach, learn about all things military at Warbird Park, tour the pleasant surroundings at Pee Dee Bicycle, and take a memorable tour with Tours.

Plan my day in Myrtle Beach using traveler tips and tourist information provided by Inspirock.

Traveling by car from Charleston to Myrtle Beach takes 2.5 hours. Alternatively, you can take a bus. March in Myrtle Beach sees daily highs of 63°F and lows of 45°F at night. Cap off your sightseeing on the 24th (Tue) early enough to travel back home.

Things to do in Myrtle Beach

Parks Outdoors Museums

Side Trips

Murrells Inlet, Barefoot Landing, Kaminski House Museum
Highlights from your plan
Ripley's Aquarium of Myrtle Beach ©
Ripley's Aquarium of Myrtle Beach
Brookgreen Gardens ©
Brookgreen Gardens
Myrtle Beach SkyWheel ©
Myrtle Beach SkyWheel

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