22 days in United States Itinerary

Writer Pearl Buck once called New York City “a place apart,” and this giant urban center remains unlike any other in the world.

New York City is known for sightseeing, museums, and nightlife. Your trip includes some of its best attractions: take in the pleasant sights at Central Park, admire the striking features of Rockefeller Center, take in panoramic vistas at Empire State Building, and don't miss a visit to Grand Central Terminal.

To see maps, more things to do, traveler tips, and other tourist information, use the New York City trip itinerary builder site.

Frankfurt, Germany to New York City is an approximately 11.5-hour flight. The time zone difference when traveling from Frankfurt to New York City is minus 6 hours. Prepare for a bit warmer weather when traveling from Frankfurt in September: high temperatures in New York City hover around 31°C and lows are around 22°C. Wrap up your sightseeing on the 14th (Thu) to allow time to take a train to Philadelphia.

Steeped in cultural and historical heritage, Philadelphia is known as the birthplace of U.S. democracy, as it was once the meeting place for the country's Founding Fathers.

On the 15th (Fri), contemplate the long history of Liberty Bell Center, then contemplate the long history of Independence Hall, then steep yourself in history at Elfreth's Alley, and finally admire the local landmark of Longwood Gardens. Get ready for a full day of sightseeing on the next day: admire the masterpieces at Philadelphia Museum of Art, then get engrossed in the history at Eastern State Penitentiary, then explore the world behind art at Barnes Foundation, and finally appreciate the history behind Rocky Statue.

To see ratings, where to stay, and more tourist information, go to the Philadelphia trip website.

Traveling by train from New York City to Philadelphia takes 1.5 hours. Alternatively, you can drive; or take a bus. In September, plan for daily highs up to 31°C, and evening lows to 20°C. Wrap up your sightseeing on the 16th (Sat) early enough to take a train to Washington DC.

The capital of the United States, the District of Columbia contains the lion's share of the country's most treasured monuments, memorials, and public museums.

Washington DC is known for sightseeing, museums, and historic sites. Your trip includes some of its best attractions: examine the collection at National Air and Space Museum, pause for some photo ops at Vietnam Veterans Memorial, ponder the world of politics at Library of Congress, and take an in-depth tour of United States Holocaust Memorial Museum.

To see other places to visit, photos, traveler tips, and tourist information, go to the Washington DC trip itinerary maker app.

You can take a train from Philadelphia to Washington DC in 2.5 hours. Other options are to drive; or take a bus. Expect a daytime high around 32°C in September, and nighttime lows around 21°C. Finish your sightseeing early on the 19th (Tue) to allow enough time to fly to Pittsburgh.

Known primarily for its steel-related heritage and 446 bridges, Pittsburgh sits at the confluence of the Monongahela and Allegheny Rivers, which meet to form the Ohio River.

Explore the numerous day-trip ideas around Pittsburgh: Fallingwater (in Mill Run) and Mister Rogers' Park Bench (in Latrobe). There's lots more to do: examine the collection at Bicycle Heaven, stop by Larrimor's, get a new perspective on things with Boat Tours & Water Sports, and take in nature's colorful creations at Phipps Conservatory and Botanical Gardens.

For maps, other places to visit, ratings, and more tourist information, refer to the Pittsburgh holiday builder.

You can fly from Washington DC to Pittsburgh in 3 hours. Alternatively, you can drive; or take a bus. Prepare for little chillier weather when traveling from Washington DC in September: high temperatures in Pittsburgh hover around 28°C and lows are around 16°C. Finish your sightseeing early on the 22nd (Fri) so you can fly to Indianapolis.

Indiana's capital and most populous city, Indianapolis is best known for its racecar events and impressive museums, and as the hometown of Kurt Vonnegut.

Start off your visit on the 23rd (Sat): don't miss a visit to USS Indianapolis Memorial, bet on your favorite at Indianapolis Motor Speedway Museum, then explore the engaging exhibits at Children's Museum of Indianapolis, and finally test your problem-solving skills at popular escape rooms. Get ready for a full day of sightseeing on the next day: make a trip to Central Canal, then try to win big at Indiana Grand Racing & Casino, and then meet the residents at Indianapolis Zoo.

Find out how to plan Indianapolis trip without stress by asking Inspirock to help create an itinerary.

Traveling by flight from Pittsburgh to Indianapolis takes 3 hours. Alternatively, you can drive; or take a bus. In September, plan for daily highs up to 31°C, and evening lows to 17°C. Finish your sightseeing early on the 24th (Sun) to allow enough time to fly to Chicago.

A huge and vibrant city, Chicago is home to top-notch theaters, shops, museums, galleries, and restaurants.

Chicago is known for sightseeing, museums, and nightlife. Your trip includes some of its best attractions: admire the masterpieces at The Art Institute of Chicago, get up close and personal with brilliant marine life at Shedd Aquarium, take a leisurely stroll along Navy Pier, and walk around Millennium Park.

To see more things to do, ratings, maps, and tourist information, use the Chicago online trip itinerary builder.

Traveling by flight from Indianapolis to Chicago takes 2.5 hours. Alternatively, you can drive; or take a bus. Due to the time zone difference, you'll gain 1 hour traveling from Indianapolis to Chicago. In September, plan for daily highs up to 30°C, and evening lows to 19°C. Finish your sightseeing early on the 27th (Wed) to allow enough time to fly to Niagara Falls.

The city of Niagara Falls houses the U.S. half of the famous waterfall that straddles the border between Canada and the United States.

On the 28th (Thu), try to win big at Seneca Niagara Resort & Casino, take in the dramatic scenery at Bridal Veil Falls, Head underground at Cave of the Winds, then enjoy breathtaking views from Niagara Falls Observation Tower, and finally make a trip to Third Street Art Alley. Get ready for a full day of sightseeing on the 29th (Fri): pause for some photo ops at Tuscarora Heroes Monument, then steep yourself in history at Frank Lloyd Wright's Martin House, then take in the spiritual surroundings of Our Lady of Victory National Shrine & Basilica, and finally get outside with Outdoor Activities.

To find traveler tips, ratings, and more tourist information, read our Niagara Falls trip planner.

Fly from Chicago to Niagara Falls in 3 hours. Alternatively, you can drive; or take a train. Traveling from Chicago to Niagara Falls, you'll lose 1 hour due to the time zone difference. Traveling from Chicago in September, Niagara Falls is a bit cooler at night with lows of 15°C. Finish your sightseeing early on the 29th (Fri) to allow enough time to travel back home.