22 days in United States Itinerary

22 days in United States Itinerary

Created using Inspirock United States sightseeing planner

Make it your trip
Fly
1
Saint Louis
— 3 nights
Drive
2
Hannibal
— 3 nights
Drive
3
Florida
— 1 night
Drive
4
Vicksburg
— 2 nights
Drive
5
Lafayette
— 3 nights
Drive
6
Baton Rouge
— 4 nights
Drive
7
New Orleans
— 4 nights
Fly

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Saint Louis

— 3 nights

Gateway to the West

Test the local claim that Saint Louis is second only to Washington, D.C.
Step off the beaten path and head to St. Charles Historic District and Missouri Civil War Museum. Popular historic sites such as Dana-Thomas House and Cahokia Mounds State Historic Site are in your itinerary. Venture out of the city with trips to Scott Field Heritage Air Park (in Belleville) and Illinois State Museum (in Springfield). There's still lots to do: admire the masterpieces at Saint Louis Art Museum, look for all kinds of wild species at The Sophia M. Sachs Butterfly House, get engrossed in the history at Missouri History Museum, and examine the collection at Cardinals Hall of Fame and Museum.

For traveler tips, other places to visit, photos, and tourist information, go to the Saint Louis trip planner.

Boston to Saint Louis is an approximately 5-hour flight. You can also drive; or take a train. The time zone changes from Eastern Standard Time to Central Standard Time, which is usually a -1 hour difference. Prepare for a bit warmer weather when traveling from Boston in May: high temperatures in Saint Louis hover around 77°F and lows are around 57°F. Finish your sightseeing early on the 4th (Mon) so you can drive to Hannibal.

Things to do in Saint Louis

Museums · Historic Sites · Wildlife · Parks

Side Trips

Hannibal

— 3 nights
Hannibal is a city in Marion and Ralls counties in the U.S. Take a break from the city and head to Zipline and Mark Twain Cave and Cameron Cave. You'll explore the less-touristy side of things at Mark Twain Boyhood Home and Rockcliffe Mansion. Explore Hannibal's surroundings by going to Audrain County Historical Museum (in Mexico) and Nauvoo (Nauvoo Temple & Historic Nauvoo).

For ratings, maps, where to stay, and more tourist information, you can read our Hannibal online route planner.

You can drive from Saint Louis to Hannibal in 2.5 hours. Alternatively, you can take a bus. In May, daytime highs in Hannibal are 75°F, while nighttime lows are 54°F. Cap off your sightseeing on the 7th (Thu) early enough to travel to Florida.

Things to do in Hannibal

Historic Sites · Museums · Adventure · Tours

Side Trips

Florida

— 1 night
Florida is an inactive village in Monroe County, Missouri, United States. Kick off your visit on the 8th (Fri): contemplate the long history of Mark Twain Birthplace State Historic Site and then immerse yourself in nature at Mark Twain State Park.

To find more things to do, photos, other places to visit, and tourist information, go to the Florida online trip itinerary planner.

You can drive from Hannibal to Florida in an hour. In May, daytime highs in Florida are 75°F, while nighttime lows are 54°F. Cap off your sightseeing on the 8th (Fri) early enough to travel to Vicksburg.

Things to do in Florida

Nature · Parks · Historic Sites

Vicksburg

— 2 nights
Vicksburg is the only city and county seat of Warren County, Mississippi, United States. Your inner history buff will appreciate Stanton Hall and Rosalie Mansion. Step off the beaten path and head to U.S.S. Cairo Museum and Jesse Brent Lower Mississippi River Museum and Interpretive Center. Explore the numerous day-trip ideas around Vicksburg: St. Mary Basilica (in Natchez) and Windsor Ruins (in Port Gibson). Next up on the itinerary: ponder the world of politics at Old Courthouse.

To find out how to plan a trip to Vicksburg, use our trip itinerary maker.

Traveling by car from Florida to Vicksburg takes 10 hours. Alternatively, you can do a combination of car and flight. Traveling from Florida in May, things will get somewhat warmer in Vicksburg: highs are around 82°F and lows about 62°F. Cap off your sightseeing on the 11th (Mon) early enough to go by car to Lafayette.

Things to do in Vicksburg

Historic Sites · Museums

Side Trips

Lafayette

— 3 nights
Lafayette is a city located along the Vermilion River in southwestern Louisiana. You'll explore the less-touristy side of things at Rip Van Winkle Gardens and Cathedral of St John the Evangelist. Vermilionville and Acadian Memorial are good opportunities to explore the local culture. Change things up with a short trip to Shadows on the Teche in New Iberia (about 34 minutes away). There's lots more to do: contemplate the waterfront views at Lake Martin, get to know the fascinating history of Acadian Village, get engrossed in the history at Acadian Cultural Center, and pause for some photo ops at Urns of Justice.

To find photos, traveler tips, ratings, and tourist information, read Lafayette day trip planning app.

Drive from Vicksburg to Lafayette in 4.5 hours. Alternatively, you can fly; or take a bus. In May, daily temperatures in Lafayette can reach 84°F, while at night they dip to 66°F. Finish your sightseeing early on the 14th (Thu) to allow enough time to drive to Baton Rouge.

Things to do in Lafayette

Historic Sites · Museums · Parks · Nature

Side Trips

Baton Rouge

— 4 nights
Baton Rouge is the capital of the U.S. You'll discover tucked-away gems like USS Kidd and Houmas House Plantation and Gardens. Your cultural itinerary includes sights like Louisiana's Old State Capitol and LSU Rural Life Museum. Change things up with these side-trips from Baton Rouge: St. Joseph Plantation (in Vacherie), Nottoway Plantation (in White Castle) and Saint Francisville (The Myrtles Plantation, Rosedown Plantation State Historic Site, &more). There's much more to do: look for all kinds of wild species at Mike the Tiger's Habitat, walk around Riverfront Plaza, pause for some serene contemplation at St. Joseph Cathedral, and get engrossed in the history at Capitol Park Museum.

To see other places to visit and tourist information, go to the Baton Rouge route app.

Traveling by car from Lafayette to Baton Rouge takes an hour. Alternatively, you can take a bus. In May in Baton Rouge, expect temperatures between 84°F during the day and 63°F at night. Finish your sightseeing early on the 18th (Mon) to allow enough time to drive to New Orleans.

Things to do in Baton Rouge

Historic Sites · Museums · Parks · Wildlife

Side Trips

New Orleans

— 4 nights

The Big Easy

Known for its Creole cuisine, rich musical tradition, and nearby swamps and plantations, New Orleans is one of the nation's oldest cities.
Museum-lovers will appreciate The National WWII Museum and New Orleans Pharmacy Museum. Get some historical perspective at Garden District and St. Louis Cathedral. There's much more to do: admire the masterpieces at The Sydney and Walda Besthoff Sculpture Garden at NOMA, stop by Boutique du Vampyre, examine the collection at Audubon Butterfly Garden and Insectarium, and take in the architecture and atmosphere at Immaculate Conception Church.

To find where to stay, reviews, other places to visit, and other tourist information, refer to the New Orleans online trip maker.

Traveling by car from Baton Rouge to New Orleans takes 1.5 hours. Alternatively, you can take a bus. Traveling from Baton Rouge in May, expect nights in New Orleans to be a bit warmer, around 70°F, while days are slightly colder, around 70°F. Wrap up your sightseeing on the 22nd (Fri) to allow time to travel back home.

Things to do in New Orleans

Museums · Historic Sites · Neighborhoods · Fun & Games

United States travel guide

4.5
Specialty Museums · Beaches · Historic Sites
More than the country of car-packed streets seen in TV shows and movies, the United States of America is a complex and diverse home to over 300 million people living in a wide range of landscapes and climates. From its big-city skyscrapers to its sprawling natural parks, the country's ''melting pot'' combines many ethnic groups that share a strong sense of national identity despite their cultural differences. A country of road trips and big blue skies, the United States harbors orderly cities filled with restaurants, parks, museums, and innumerable sightseeing opportunities, as well as pristine natural areas perfect for a holiday in the great outdoors. To see as much as you can of this diverse land quickly, drive over some of the more than 6 million km (4 million mi) of highways leading through deserts, mountain peaks, fertile fields, and giant urban centers.