25 days in South Carolina Itinerary

25 days in South Carolina Itinerary

Created using Inspirock South Carolina holiday planner

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Route & dates

25 days in South Carolina Itinerary

Start: San Francisco
Fly + taxi:  8​h 15​min
1
Greenville
— 1 night
bus:  1​h 30​min
2
Columbia
— 3 nights
Drive:  3​h
3
Hilton Head
— 4 nights
Drive:  1​h 15​min
4
Beaufort
— 3 nights
Drive:  1​h 45​min
5
Charleston
— 4 nights
Drive:  3​h
6
Edisto Island
— 2 nights
Drive:  5​h 45​min
7
Myrtle Beach
— 3 nights
Drive:  3​h 15​min
8
Walterboro
— 2 nights
Drive + Fly:  11​h 30​min
End: San Francisco

1
night
Greenville

Greenville ©
The largest city in "upstate" South Carolina, Greenville has grown around the natural wonders of waterfalls located in the downtown area.
Start off your visit on the 10th (Sun): snap pictures at Liberty Bridge, then explore the engaging exhibits at The Children's Museum of the Upstate, then test your team's savvy at popular escape rooms, and finally stroll through Cleveland Park. Get ready for a full day of sightseeing on the 11th (Mon): grab your bike and head to GHS Swamp Rabbit Trail, then explore and take pictures at Fluor Field at the WestEnd, and then sample the fine beverages at Dark Corner Distillery.

To see traveler tips, where to stay, reviews, and tourist information, use the Greenville driving holiday planner .

San Francisco to Greenville is an approximately 8.5-hour combination of flight and taxi. You can also do a combination of flight and bus; or drive. Due to the time zone difference, you'll lose 3 hours traveling from San Francisco to Greenville. Traveling from San Francisco in March, plan for little chillier nights in Greenville, with lows around 43°F. Cap off your sightseeing on the 11th (Mon) early enough to catcht the bus to Columbia.

Things to do in Greenville

Parks Trails Outdoors
Highlights from your plan
Cleveland Park ©
Cleveland Park
Fluor Field at the WestEnd ©
Fluor Field at the WestEnd
Liberty Bridge ©
Liberty Bridge

3
nights
Columbia

Columbia ©
A compact capital with stately southern history, Columbia serves as a symbol of the south.
Eschew the tourist crowds and head to Fort Jackson National Cemetery and Aiken Center for the Arts. Change things up with these side-trips from Columbia: Cyndi's Sweet Shoppe (in Aiken), Camden Revolutionary War Site (in Camden) and Dreher Island State Park (in Prosperity). There's much more to do: admire the majestic nature at Poinsett State Park, get engrossed in the history at South Carolina Confederate Relic Room and Military Museum, pause for some serene contemplation at St. Peter's Catholic Church, and learn about all things military at South Carolina Military Museum.

To see reviews, more things to do, where to stay, and tourist information, use the Columbia vacation builder website .

Traveling by bus from Greenville to Columbia takes 1.5 hours. Alternatively, you can drive. In March, daily temperatures in Columbia can reach 67°F, while at night they dip to 44°F. Finish your sightseeing early on the 14th (Thu) to allow enough time to drive to Hilton Head.

Things to do in Columbia

Nature Parks Historic Sites

Side Trips

Aiken, Poinsett State Park, Dreher Island State Park, Camden Revolutionary War Site
Highlights from your plan
Harbison State Forest ©
Harbison State Forest
Aiken Center for the Arts ©
Aiken Center for the Arts

4
nights
Hilton Head

Hilton Head ©
A Hilton Head vacation may be heaven for a golfer, but the area also offers all kinds of other options for sports fans.
Step off the beaten path and head to Sea Pines Forest Preserve and Coastal Discovery Museum. There's lots more to do: get some thrills out on the water with a waterskiing or jet-skiing adventure, try for a hole-in-one at Legendary Golf, see what you can catch with a fishing tour, and choose your vessel at Shelter Cove Harbour & Marina.

For photos, other places to visit, reviews, and other tourist information, you can read our Hilton Head trip itinerary planner.

Getting from Columbia to Hilton Head by car takes about 3 hours. Other options: do a combination of train and taxi; or take a bus. Traveling from Columbia in March, expect somewhat warmer with lows of 50°F in Hilton Head. Cap off your sightseeing on the 18th (Mon) early enough to go by car to Beaufort.

Things to do in Hilton Head

Parks Outdoors Wildlife
Highlights from your plan
Sea Pines Forest Preserve ©
Sea Pines Forest Preserve
Hilton Head Boathouse ©
Hilton Head Boathouse
Folly Field Beach Park ©
Folly Field Beach Park

3
nights
Beaufort

Beaufort ©
Beaufort is a city in and the county seat of Beaufort County, South Carolina, United States. Explore hidden gems such as Spanish Moss Trail and Charles Street Gallery. Change things up with these side-trips from Beaufort: Carolina Cider Company (in Yemassee) and Bluffton (Heyward House Museum & Welcome Center & Spas & Wellness). There's still lots to do: see the interesting displays at Pat Conroy Literary Center, identify plant and animal life at Cypress Wetlands, get engrossed in the history at Beaufort History Museum, and get a taste of the local shopping with Rhett Gallery.

To find more things to do, ratings, reviews, and other tourist information, read our Beaufort trip itinerary builder .

You can drive from Hilton Head to Beaufort in 1.5 hours. Another option is to take a bus. In March in Beaufort, expect temperatures between 67°F during the day and 48°F at night. Finish your sightseeing early on the 21st (Thu) so you can drive to Charleston.

Things to do in Beaufort

Museums Parks Shopping

Side Trips

Carolina Cider Company, Heyward House Museum & Welcome Center, Cypress Wetlands
Highlights from your plan
Pat Conroy Literary Center ©
Pat Conroy Literary Center
Spanish Moss Trail ©
Spanish Moss Trail
Cypress Wetlands ©
Cypress Wetlands

4
nights
Charleston

Charleston ©
Many visitors describe their Charleston holiday as a warm embrace by an old, dear friend--who lived about 200 years ago.
Eschew the tourist crowds and head to Fort Moultrie and Cathedral of Saint John the Baptist. Go for a jaunt from Charleston to Awendaw to see The Center for Birds of Prey about 38 minutes away. And it doesn't end there: cast your line with a fishing tour, test your team's savvy at popular escape rooms, take an in-depth tour of The Charleston Museum, and get up close to creatures of the deep with a dolphin and whale watching tour.

To see more things to do, reviews, where to stay, and other tourist information, you can read our Charleston travel route planner .

Traveling by car from Beaufort to Charleston takes 2 hours. Alternatively, you can take a bus. In March, daytime highs in Charleston are 66°F, while nighttime lows are 47°F. Finish your sightseeing early on the 25th (Mon) so you can travel to Edisto Island.

Things to do in Charleston

Wildlife Parks Historic Sites

Side Trips

Mount Pleasant, Fort Moultrie, The Center for Birds of Prey, Dolphin & Whale Watching
Highlights from your plan
St. Michael's Church ©
St. Michael's Church
Shem Creek Park ©
Shem Creek Park
College of Charleston ©
College of Charleston

2
nights
Edisto Island

Edisto Island
Edisto Island is one of South Carolina's Sea Islands, the larger part of which lies in Charleston County, with its southern tip in Colleton County. Kick off your visit on the 26th (Tue): look for gifts at With These Hands Gallery, go for a stroll along the water at The Marina at Edisto Beach, and then play a few rounds at The Plantation Course at Edisto. On your second day here, identify plant and animal life at Botany Bay Plantation Heritage Preserve and Wildlife Management Area, then browse the fresh offerings at Kings Farm Market, and then examine the collection at Edisto Island Museum.

For photos, other places to visit, where to stay, and tourist information, you can read our Edisto Island online attractions planner .

You can drive from Charleston to Edisto Island in 1.5 hours. In March, daytime highs in Edisto Island are 66°F, while nighttime lows are 47°F. Finish up your sightseeing early on the 27th (Wed) so you can travel to Myrtle Beach.

Things to do in Edisto Island

Parks Outdoors Golf
Highlights from your plan

3
nights
Myrtle Beach

Myrtle Beach is a coastal city on the east coast of the United States in Horry County, South Carolina. Step off the beaten path and head to Nature & Wildlife Tours and Historic District. Venture out of the city with trips to North Carolina Aquarium at Fort Fisher (in Kure Beach), Southport (Franklin Square Gallery & Trinity United Methodist Church) and Wilmington (Airlie Gardens & Riverwalk). There's much more to do: test your team's savvy at popular escape rooms, admire all the interesting features of Myrtle Beach Pelicans, take in the waterfront at MarshWalk, and examine the collection at Hollywood Wax Museum.

For maps, traveler tips, more things to do, and other tourist information, refer to the Myrtle Beach trip maker website .

Drive from Edisto Island to Myrtle Beach in 3 hours. In March in Myrtle Beach, expect temperatures between 63°F during the day and 45°F at night. Finish your sightseeing early on the 31st (Sun) so you can travel to Walterboro.

Things to do in Myrtle Beach

Outdoors Golf Wildlife

Side Trips

Wilmington, Southport, North Carolina Aquarium at Fort Fisher, MarshWalk
Highlights from your plan
Nature & Wildlife Tours
Airlie Gardens ©
Airlie Gardens
Historic District ©
Historic District

2
nights
Walterboro

Walterboro ©
Walterboro is a city in Colleton County, South Carolina, United States. Kick off your visit on the 1st (Mon): steep yourself in history at Rivers Bridge State Historic Site, look for all kinds of wild species at Walterboro Wildlife Sanctuary, then see the interesting displays at Colleton Museum and Farmers Market, and finally examine the collection at Slave Relic Museum.

To find where to stay, photos, and other tourist information, you can read our Walterboro trip planning tool .

Traveling by car from Myrtle Beach to Walterboro takes 3 hours. In March in Walterboro, expect temperatures between 67°F during the day and 44°F at night. On the 2nd (Tue), wrap the sightseeing up by early afternoon so you can travel back home.

Things to do in Walterboro

Museums Wildlife Breweries & Distilleries

Side Trips

Rivers Bridge State Historic Site, Lucky Duck Distillery
Highlights from your plan
Colleton  Museum and Farmers Market ©
Walterboro Wildlife Sanctuary ©
Walterboro Wildlife Sanctuary
Rivers Bridge State Historic Site ©
Rivers Bridge State Historic Site

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