28 days in East Coast of USA Itinerary

Asheville nestles between two major mountain ranges in the scenic western section of North Carolina.

Step out of the city life by going to Blue Ridge Pkwy and The North Carolina Arboretum. You'll explore the less-touristy side of things at Chimney Rock at Chimney Rock State Park and Tumblestone Tours and Transportation. And it doesn't end there: whizz through the canopy at Navitat Canopy Adventures - Asheville Zipline, indulge in some personalized pampering at some of the best spas, and indulge your thirst for a good beer at Sierra Nevada Brewing Co. Tours & Tastings.

For other places to visit, ratings, more things to do, and tourist information, use the Asheville online trip itinerary planner.

New York City to Asheville is an approximately 5.5-hour flight. You can also drive; or take a bus. Traveling from New York City in October, plan for slightly colder nights in Asheville, with lows around 47°F. Wrap up your sightseeing on the 1st (Sun) to allow time to travel to Panama City Beach.

Boasting 43 km (27 mi) of white sandy beaches and plenty of sunshine, Panama City Beach is an ideal choice for a relaxing holiday.

Discover out-of-the-way places like Scuba & Snorkeling and St. Andrews State Park. We've included these beaches for you: Panama City Beach and Henderson Beach State Park. Take a break from Panama City Beach with a short trip to Okaloosa Island in Fort Walton Beach, about 1h 20 min away. The adventure continues: learn about winemaking at Panama City Beach Winery and browse the different shops at Pier Park.

To find photos, more things to do, other places to visit, and other tourist information, you can read our Panama City Beach trip planner.

Traveling by flight from Asheville to Panama City Beach takes 5.5 hours. Alternatively, you can drive. In November, Panama City Beach is somewhat warmer than Asheville - with highs of 74°F and lows of 49°F. Finish your sightseeing early on the 4th (Wed) so you can travel to Key West.

Located just 140 km (90 mi) from Cuba, Key West is an island only about 6.4 km (4 mi) long and 1.6 km (1 mi) wide.

Step off the beaten path and head to Fort Zachary Taylor and Dry Tortugas National Park. Take a break from the city and head to Fishing Charters & Tours and The Overseas Highway. There's still lots to do: identify plant and animal life at Key West Butterfly & Nature Conservatory and steep yourself in history at Truman Little White House.

Take the guesswork out of planning a Key West vacation by using our trip itinerary maker.

You can fly from Panama City Beach to Key West in 6 hours. Alternatively, you can drive. When traveling from Panama City Beach in November, plan for somewhat warmer days and warmer nights in Key West: temperatures range from 81°F by day to 73°F at night. Finish your sightseeing early on the 7th (Sat) to allow enough time to drive to Marathon.

A tiny city just 16 km (10 mi) long, Marathon is spread across several islands in the middle of the Florida Keys.

On the 8th (Sun), snap pictures at Seven Mile Bridge, identify plant and animal life at The Turtle Hospital, and then see some colorful creatures with a scuba or snorkeling tour. On your second day here, identify plant and animal life at Dolphin Research Center, then stroll through Bahia Honda State Park, and then take the plunge with Skydive Key West.

For other places to visit, reviews, and more tourist information, use the Marathon trip itinerary maker site.

Drive from Key West to Marathon in 1.5 hours. Alternatively, you can take a bus. November in Marathon sees daily highs of 82°F and lows of 72°F at night. Finish your sightseeing early on the 9th (Mon) so you can drive to Key Largo.

The northernmost island of the Florida Keys, Key Largo provides stunning scenery, a number of watersports opportunities, and plenty of areas to relax on vacation.

Start off your visit on the 10th (Tue): take a tour of African Queen Canal Cruise, get close to the beloved marine mammals with Theater of the Sea, and then relax and rejuvenate at Island Flow Yoga. Get ready for a full day of sightseeing on the 11th (Wed): see the vivid underwater world at Spiegel Grove, immerse yourself in nature at John Pennekamp Coral Reef State Park, and then identify plant and animal life at Florida Keys Wild Bird Rehabilitation Center.

For other places to visit, where to stay, more things to do, and other tourist information, use the Key Largo online trip builder.

Drive from Marathon to Key Largo in 1.5 hours. Alternatively, you can take a bus. In November in Key Largo, expect temperatures between 81°F during the day and 68°F at night. Finish your sightseeing early on the 11th (Wed) to allow enough time to drive to Marco Island.

Marco Island is a city in Collier County, Florida, United States, located on an island by the same name in the Gulf of Mexico off the coast of Southwest Florida. On the 12th (Thu), stroll through South Marco Beach and then get a new perspective on things with Boat Tours & Water Sports. On your second day here, surround yourself with nature on a nature and wildlife tour.

To find other places to visit, reviews, ratings, and tourist information, refer to the Marco Island trip planner.

You can drive from Key Largo to Marco Island in 3 hours. Other options are to do a combination of bus and taxi; or do a combination of bus and ferry. Expect a daytime high around 81°F in November, and nighttime lows around 64°F. Wrap up your sightseeing by early afternoon on the 13th (Fri) to allow enough time to drive to St. Augustine.

St. You'll explore the less-touristy side of things at St. Augustine Beach and St. Augustine Alligator Farm Zoological Park. Get outdoors at Ormond Beach and Beach at Daytona Beach. There's much more to do: brush up on your knowledge of spirits at St. Augustine Distillery, make a trip to St. George Street, gain insight at Flagler College, and enjoy the sea views from St. Augustine Lighthouse & Maritime Museum, Inc..

To see more things to do, photos, ratings, and more tourist information, use the St. Augustine attractions planner.

Getting from Marco Island to St. Augustine by car takes about 6 hours. Other options: do a combination of bus and flight; or do a combination of taxi and bus. In November, St. Augustine is little chillier than Marco Island - with highs of 73°F and lows of 59°F. Finish your sightseeing early on the 16th (Mon) so you can drive to Hilton Head.

A Hilton Head vacation may be heaven for a golfer, but the area also offers all kinds of other options for sports fans.

Eschew the tourist crowds and head to Dolphin & Whale Watching and Coligny Beach. Take a break from the city and head to Hilton Head Island Bike Trails and Sea Pines Forest Preserve. You'll find plenty of places to visit near Hilton Head: Beaufort (Horse-Drawn Carriage Tours & Hunting Island State Park). And it doesn't end there: look for all kinds of wild species at Pinckney Island National Wildlife Refuge, get interesting insight from Hilton Head Heli Tours, and relax and rejuvenate at some of the best spas.

To find other places to visit, maps, and other tourist information, read our Hilton Head tour itinerary planner.

You can drive from St. Augustine to Hilton Head in 4 hours. Other options are to do a combination of bus, train, and taxi; or fly. Traveling from St. Augustine in November, things will get a bit cooler in Hilton Head: highs are around 68°F and lows about 51°F. Wrap up your sightseeing on the 19th (Thu) early enough to drive to Charleston.

Many visitors describe their Charleston holiday as a warm embrace by an old, dear friend--who lived about 200 years ago.

Discover out-of-the-way places like Dolphin & Whale Watching and Angel Oak Tree. Escape the urban bustle at The Center for Birds of Prey and Horse-Drawn Carriage Tours. And it doesn't end there: walk around Joe Riley Waterfront Park, snap pictures at Arthur Ravenel Jr. Bridge, steep yourself in history at Boone Hall Plantation, and learn about all things military at Patriots Point.

To find photos and tourist information, refer to the Charleston sightseeing planner.

Drive from Hilton Head to Charleston in 2.5 hours. Alternatively, you can take a bus. In November, daytime highs in Charleston are 68°F, while nighttime lows are 49°F. Finish up your sightseeing early on the 22nd (Sun) so you can travel to New York City.

Writer Pearl Buck once called New York City “a place apart,” and this giant urban center remains unlike any other in the world.

You'll discover tucked-away gems like New York Public Library and St. Patrick's Cathedral. There's much more to do: go for a walk through Central Park, stop by Times Square, make a trip to Grand Central Terminal, and walk around The High Line.

For other places to visit, where to stay, more things to do, and tourist information, you can read our New York City online itinerary planner.

Traveling by flight from Charleston to New York City takes 5 hours. Alternatively, you can drive; or take a bus. Plan for a bit cooler temperatures traveling from Charleston in November, with highs in New York City at 57°F and lows at 44°F. Wrap up your sightseeing on the 26th (Thu) early enough to travel back home.