4 days in South Carolina Itinerary

The largest city in "upstate" South Carolina, Greenville has grown around the natural wonders of waterfalls located in the downtown area.

On the 11th (Thu), brush up on your knowledge of spirits at Dark Corner Distillery, then take in the views from Liberty Bridge, and then take in the dramatic scenery at Falls Park on the Reedy.

For more things to do, where to stay, traveler tips, and tourist information, go to the Greenville trip itinerary planning app .

Augusta to Greenville is an approximately 3-hour car ride. You can also take a bus. Traveling from Augusta in October, Greenville is little chillier at night with lows of 54°F. Wrap up your sightseeing on the 11th (Thu) early enough to travel to Myrtle Beach.

Myrtle Beach is a coastal city on the east coast of the United States in Horry County, South Carolina. On the 12th (Fri), take a stroll through Broadway at the Beach, then get your game on at Backstage Mirror Maze, then admire nature's wide array of creatures at Ripley's Aquarium, and finally experience the excitement of Myrtle Beach SkyWheel.

For reviews, ratings, photos, and tourist information, read Myrtle Beach trip builder tool .

Traveling by combination of taxi and flight from Greenville to Myrtle Beach takes 4 hours. Alternatively, you can drive; or take a bus. In October, daily temperatures in Myrtle Beach can reach 76°F, while at night they dip to 59°F. Finish up your sightseeing early on the 12th (Fri) so you can travel to Edisto Island.

Edisto Island is one of South Carolina's Sea Islands, the larger part of which lies in Charleston County, with its southern tip in Colleton County. On the 13th (Sat), look for gifts at With These Hands Gallery, then immerse yourself in nature at Edisto Beach State Park, and then identify plant and animal life at Botany Bay Plantation Heritage Preserve and Wildlife Management Area.

Take the guesswork out of planning a Edisto Island vacation by using our trip itinerary maker.

Drive from Myrtle Beach to Edisto Island in 3 hours. In October, plan for daily highs up to 78°F, and evening lows to 60°F. Finish up your sightseeing early on the 13th (Sat) so you can travel to Charleston.

Many visitors describe their Charleston holiday as a warm embrace by an old, dear friend--who lived about 200 years ago.

Start off your visit on the 14th (Sun): contemplate the long history of Nathaniel Russell House, then admire all the interesting features of Riley Waterfront Park, then settle in for a delightful tour with a horse-drawn carriage tour, and finally get the lay of the land with Walking tours.

To see reviews, other places to visit, maps, and more tourist information, go to the Charleston trip itinerary planning app .

You can drive from Edisto Island to Charleston in 1.5 hours. In October, daily temperatures in Charleston can reach 78°F, while at night they dip to 60°F. Finish up your sightseeing early on the 14th (Sun) so you can go by car back home.