5 days in South Carolina Itinerary

5 days in South Carolina Itinerary

Created using Inspirock South Carolina trip itinerary planner

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Route & dates

5 days in South Carolina Itinerary

Start: Boston
Fly + taxi:  5​h 45​min
1
Greenville
— Few hours
Drive:  4​h 30​min
2
Hilton Head
— 1 night
Drive:  2​h 30​min
3
Charleston
— 2 nights
Drive:  2​h
4
Murrells Inlet
— 1 night
Fly:  3​h 45​min
End: Boston

few
hours
Greenville

Greenville ©
The largest city in "upstate" South Carolina, Greenville has grown around the natural wonders of waterfalls located in the downtown area.
To see maps, photos, where to stay, and tourist information, refer to the Greenville trip builder tool .

Boston to Greenville is an approximately 6-hour combination of bus, flight, and taxi. You can also do a combination of bus, flight, and train; or drive. Traveling from Boston in October, expect nights in Greenville to be about the same, around 54°F, while days are a bit warmer, around 75°F. Wrap up your sightseeing on the 25th (Thu) to allow time to travel to Hilton Head.

Things to do in Greenville

Nature Parks
Highlights from your plan
Falls Park on the Reedy ©
Falls Park on the Reedy

1
night
Hilton Head

A Hilton Head vacation may be heaven for a golfer, but the area also offers all kinds of other options for sports fans.
On the 26th (Fri), stroll through Hilton Head Island Bike Trails, identify plant and animal life at Wildlife Areas, and then get some thrills on the water with a speed boat tour.

To see maps, other places to visit, where to stay, and more tourist information, refer to the Hilton Head trip planner .

Traveling by combination of taxi and flight from Greenville to Hilton Head takes 4.5 hours. Alternatively, you can drive; or take a bus. Traveling from Greenville in October, plan for somewhat warmer nights in Hilton Head, with lows around 62°F. Finish your sightseeing early on the 26th (Fri) to allow enough time to drive to Charleston.

Things to do in Hilton Head

Outdoors Wildlife Tours
Highlights from your plan
Dolphin & Whale Watching
Speed Boats Tours
Hilton Head Island Bike Trails ©
Hilton Head Island Bike Trails

2
nights
Charleston

Many visitors describe their Charleston holiday as a warm embrace by an old, dear friend--who lived about 200 years ago.
On the 27th (Sat), take an in-depth tour of Fort Sumter National Monument, look for all kinds of wild species at The Center for Birds of Prey, and then contemplate the long history of Boone Hall Plantation. On your second day here, admire the natural beauty at Magnolia Plantation & Gardens and then go for a charming ride with a horse-drawn carriage tour.

To find more things to do, other places to visit, traveler tips, and more tourist information, you can read our Charleston itinerary builder website .

You can drive from Hilton Head to Charleston in 2.5 hours. Another option is to take a bus. In October, plan for daily highs up to 78°F, and evening lows to 60°F. Cap off your sightseeing on the 28th (Sun) early enough to go by car to Murrells Inlet.

Things to do in Charleston

Historic Sites Parks Wildlife

Side Trips

The Center for Birds of Prey, Boone Hall Plantation
Highlights from your plan
Horse-Drawn Carriage Tours
Fort Sumter National Monument ©
Fort Sumter National Monument
Magnolia Plantation & Gardens ©
Magnolia Plantation & Gardens

1
night
Murrells Inlet

Murrells Inlet ©
Murrells Inlet is an unincorporated area and census-designated place straddling the line between Horry and Georgetown Counties in South Carolina, United States. Kick off your visit on the 29th (Mon): tour the pleasant surroundings at Myrtle Beach and then take in nature's colorful creations at Brookgreen Gardens.

To see reviews, more things to do, ratings, and other tourist information, refer to the Murrells Inlet travel route planning website .

Traveling by car from Charleston to Murrells Inlet takes 2 hours. Alternatively, you can do a combination of bus and taxi. In October in Murrells Inlet, expect temperatures between 76°F during the day and 59°F at night. Cap off your sightseeing on the 29th (Mon) early enough to travel back home.

Things to do in Murrells Inlet

Parks Beaches Outdoors

Side Trip

Myrtle Beach
Highlights from your plan
Brookgreen Gardens ©
Brookgreen Gardens
Myrtle Beach ©
Myrtle Beach

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