52 days in Southeast Missouri Itinerary

Change things up with these side-trips from Eureka: Sullivan (Caveman Zipline, Meramec State Park, &more) and New Haven (Pinckney Bend Distillery & John Colter Memorial).

For reviews, photos, traveler tips, and other tourist information, go to the Eureka trip tool.

Belleville to Eureka is an approximately 1-hour car ride. In September in Eureka, expect temperatures between 83°F during the day and 58°F at night. On the 17th (Thu), you're off to Rolla.

Venture out of the city with trips to Steelville (Bass River Resort, Huzzah Valley Resort, &more), Leasburg (Belmont Vineyards & Winery, Onondaga Cave State Park, &more) and New Haven (Robller Vineyard, Astral Glass Studio and Gallery, &more). Make the 23rd (Wed) an awe-inspiring day at Mark Twain National Forest.

Quickly create a custom-made itinerary for Rolla using our trip planner.

Drive from Eureka to Rolla in 1.5 hours. In September, daily temperatures in Rolla can reach 81°F, while at night they dip to 59°F. You'll set off for Eminence on the 25th (Fri).

Get out of town with these interesting Eminence side-trips: Van Buren (Missouri Down Under, Big Spring, &more), Salem (Bo's Hollow & Montauk State Park) and West Plains (Ozark Heritage Welcome Center, Escape West Plains, &more). Spend the 26th (Sat) exploring nature at Alley Spring Grist Mill Historic Site.

For where to stay, reviews, photos, and tourist information, read Eminence journey planner.

Traveling by car from Rolla to Eminence takes 1.5 hours. Expect a daytime high around 83°F in September, and nighttime lows around 59°F. Wrap up your sightseeing on the 3rd (Sat) to allow time to drive to Middle Brook.

Middle Brook is known for nature. Your trip includes some of its best attractions: immerse yourself in nature at Johnson's Shut-ins State Park.

To see maps, where to stay, more things to do, and tourist information, refer to the Middle Brook trip planner.

Getting from Eminence to Middle Brook by car takes about 1.5 hours. In October, daytime highs in Middle Brook are 70°F, while nighttime lows are 48°F. You'll set off for Cape Girardeau on the 12th (Mon).

Explore the numerous day-trip ideas around Cape Girardeau: New Madrid (Hunter-Dawson State Historic Site, New Madrid Historical Museum, &more) and Sikeston (Sikeston Depot Museum & Gallery & Malco Sikeston Cinema and Grill).

For maps, ratings, photos, and other tourist information, refer to the Cape Girardeau trip itinerary builder website.

You can drive from Middle Brook to Cape Girardeau in 2 hours. In October, plan for daily highs up to 73°F, and evening lows to 48°F. Finish your sightseeing early on the 21st (Wed) so you can drive to Sainte Genevieve.

Explore the numerous day-trip ideas around Sainte Genevieve: Arcadia Valley (in Arcadia) and Bonne Terre (The Space Museum, Bonne Terre Mine Tours - West End Diving, &more).

To see reviews, more things to do, and more tourist information, use the Sainte Genevieve trip itinerary website.

You can drive from Cape Girardeau to Sainte Genevieve in 1.5 hours. In October, plan for daily highs up to 70°F, and evening lows to 49°F. Wrap up your sightseeing on the 30th (Fri) to allow time to drive back home.