59 days in South Carolina Itinerary
Created using Inspirock South Carolina trip itinerary planner
Start: North Myrtle Beach
Drive
1
Charleston
— 11 nights
Drive
2
Kiawah Island
— 2 nights
Unknown
3
Edisto Island
— 4 nights
Drive
4
Beaufort
— 7 nights
Drive
5
Hilton Head
— 10 nights
Fly
6
Greenville
— 6 nights
Drive
7
Columbia
— 4 nights
Drive
8
Myrtle Beach
— 9 nights
Drive
9
Pawleys Island
— 5 nights
Drive
End: Charleston
Sat, Mar 19 - Mon, May 16
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Charleston — 11 nights
Many visitors describe their Charleston holiday as a warm embrace by an old, dear friend--who lived about 200 years ago.The Charleston Museum and North Charleston and American LaFrance Fire Museum and Educational Center will appeal to museum buffs. McLeod Plantation Historic Site and Cathedral of Saint John the Baptist will appeal to history buffs. Get out of town with these interesting Charleston side-trips: Caw Caw Interpretive Center (in Ravenel), Cypress Gardens (in Moncks Corner) and Colonial Dorchester State Historic Site (in Summerville). The adventure continues: steep yourself in history at Heyward-Washington House, get a dose of the wild on Charleston Fossil Adventures, get outside with Outdoor Activities, and appreciate the history behind Fort Moultrie.
To see other places to visit, maps, traveler tips, and other tourist information, go to the Charleston trip planner.
North Myrtle Beach to Charleston is an approximately 3-hour car ride. You can also do a combination of taxi and bus. Expect a daytime high around 66°F in March, and nighttime lows around 47°F. Cap off your sightseeing on the 30th (Wed) early enough to go by car to Kiawah Island.
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Kiawah Island — 2 nights
Kiawah is a sea island, or barrier island, on the Atlantic coast of the United States. On the 30th (Wed), play a few rounds at Turtle Point Golf Course and then stop by Kiawah Fine Jewelry. On the next day, make a trip to Thompson Park and then pause for some serene contemplation at Stella Maris Roman Catholic Church.
Find out how to plan Kiawah Island trip without stress by asking Inspirock to help create an itinerary.
You can drive from Charleston to Kiawah Island in an hour. Alternatively, you can drive. In March in Kiawah Island, expect temperatures between 66°F during the day and 47°F at night. Wrap up your sightseeing on the 1st (Fri) to allow time to travel to Edisto Island.
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Find out how to plan Kiawah Island trip without stress by asking Inspirock to help create an itinerary.
You can drive from Charleston to Kiawah Island in an hour. Alternatively, you can drive. In March in Kiawah Island, expect temperatures between 66°F during the day and 47°F at night. Wrap up your sightseeing on the 1st (Fri) to allow time to travel to Edisto Island.
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Edisto Island — 4 nights
Edisto Island is one of South Carolina's Sea Islands, the larger part of which lies in Charleston County, with its southern tip in Colleton County. You'll discover tucked-away gems like Indian Mound Trail and The Plantation Course at Edisto. Get some cultural insight at Fort Fremont and Edisto Island Museum. Next up on the itinerary: cast your line with Fontaine Charters, take in the waterfront activity at The Marina at Edisto Beach, pick up some local products at Kings Farm Market, and look for gifts at With These Hands Gallery.
For more things to do, photos, maps, and other tourist information, you can read our Edisto Island journey planner.
You can travel from Kiawah Island to Edisto Island in 1.5 hours. Alternatively, you can travel. Expect a daytime high around 74°F in April, and nighttime lows around 57°F. Finish up your sightseeing early on the 5th (Tue) so you can go by car to Beaufort.
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For more things to do, photos, maps, and other tourist information, you can read our Edisto Island journey planner.
You can travel from Kiawah Island to Edisto Island in 1.5 hours. Alternatively, you can travel. Expect a daytime high around 74°F in April, and nighttime lows around 57°F. Finish up your sightseeing early on the 5th (Tue) so you can go by car to Beaufort.
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Beaufort — 7 nights
Beaufort is a city in and the county seat of Beaufort County, South Carolina, United States. Your cultural itinerary includes sights like Rivers Bridge State Historic Site and Saint Peter's Catholic Church. Museum-lovers will appreciate Santa Elena History Center and Morris Center for Lowcountry Heritage. Get out of town with these interesting Beaufort side-trips: Bear Island Wildlife Management Area (in Green Pond), Sergeant Jasper County Park (in Hardeeville) and Colleton Museum and Farmers Market (in Walterboro). Next up on the itinerary: paddle through the water with a kayaking and canoeing tour, take in the architecture and atmosphere at Tabernacle Baptist Church, take in the exciting artwork at Atelier on Bay, and get a taste of the local shopping with Thibault Gallery.
To see photos, where to stay, traveler tips, and tourist information, read Beaufort online journey planner.
Traveling by car from Edisto Island to Beaufort takes 1.5 hours. Alternatively, you can drive. In April in Beaufort, expect temperatures between 75°F during the day and 58°F at night. Cap off your sightseeing on the 12th (Tue) early enough to go by car to Hilton Head.
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To see photos, where to stay, traveler tips, and tourist information, read Beaufort online journey planner.
Traveling by car from Edisto Island to Beaufort takes 1.5 hours. Alternatively, you can drive. In April in Beaufort, expect temperatures between 75°F during the day and 58°F at night. Cap off your sightseeing on the 12th (Tue) early enough to go by car to Hilton Head.
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Hilton Head — 10 nights

A Hilton Head vacation may be heaven for a golfer, but the area also offers all kinds of other options for sports fans.Head to Shelter Cove Towne Centre and Nash Galleryfor some retail therapy. Take a break from the city and head to May River Excursions and Arthur Hills Golf Course. Change things up with these side-trips from Hilton Head: Parris Island Museum (in Parris Island) and Saint Helena Island (Saint Helena Parish Chapel of Ease Ruins & Penn Center). Next up on the itinerary: enjoy the sand and surf at Folly Field Beach Park, stop by Old Town Bluffton, walk around Driessen Beach Park, and tee off at The Golf Courses of Palmetto Dunes.
To find maps, more things to do, and other tourist information, go to the Hilton Head vacation planner.
Getting from Beaufort to Hilton Head by car takes about an hour. Other options: take a bus. Expect a daytime high around 74°F in April, and nighttime lows around 59°F. Wrap up your sightseeing on the 22nd (Fri) to allow time to fly to Greenville.
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Greenville — 6 nights

Textile Center of the World
The largest city in "upstate" South Carolina, Greenville has grown around the natural wonders of waterfalls located in the downtown area.Appreciate the collections at Bob Jones University Museum & Gallery and Shoeless Joe Jackson Museum and Baseball Library. Do some cultural sightseeing at Upcountry History Museum and Museum and Library of Confederate History. Explore the numerous day-trip ideas around Greenville: Tryon Horse Country Tours (in Tryon), Pearson's Falls and Glen (in Saluda) and Walhalla (Stumphouse Mountain Tunnel & Issaqueena Falls). There's lots more to do: admire the masterpieces at Greenville County Museum of Art, look for all kinds of wild species at Lake Conestee Nature Park, let the kids burn off some steam at Runway Park at GMU, and stop by Mice on Main.
To see photos, other places to visit, maps, and other tourist information, use the Greenville trip itinerary app.
Getting from Hilton Head to Greenville by flight takes about 4.5 hours. Other options: drive; or do a combination of taxi and bus. Expect a bit cooler evenings in Greenville when traveling from Hilton Head in April, with lows around 53°F. Finish your sightseeing early on the 28th (Thu) so you can drive to Columbia.
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Columbia — 4 nights
Capital of Southern Hospitality
A compact capital with stately southern history, Columbia serves as a symbol of the south.Your inner history buff will appreciate St. John's Episcopal Church and Trinity Episcopal Cathedral. Do some cultural sightseeing at The South Carolina Cotton Museum and Robert Mills House & Gardens. And it doesn't end there: identify plant and animal life at Congaree Creek Heritage Preserve, hunt for treasures at Soda City Market, stroll through Timmerman Trail, and hike along Harbison Neighborhood Trails.
To see more things to do, where to stay, other places to visit, and tourist information, you can read our Columbia trip planner.
Traveling by car from Greenville to Columbia takes 2 hours. Alternatively, you can take a bus. In April, daytime highs in Columbia are 77°F, while nighttime lows are 54°F. Wrap up your sightseeing on the 2nd (Mon) to allow time to drive to Myrtle Beach.
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Myrtle Beach — 9 nights

Myrtle Beach is a coastal city on the east coast of the United States in Horry County, South Carolina. Museum-lovers will get to explore Hollywood Wax Museum and Myrtle Beach Pinball Museum. Escape the urban bustle at Mt. Atlanticus and Off-Road Tours. Get out of town with these interesting Myrtle Beach side-trips: Callahan's of Calabash (in Calabash) and Cherry Grove Beach (in North Myrtle Beach). There's still lots to do: examine the collection at Wheels of Yesteryear, admire the masterpieces at Franklin G. Burroughs - Simeon B. Chapin Art Museum, revel in the low prices at Tanger Outlets Myrtle Beach Hwy 17, and browse the different shops at The Market Common.
To see reviews, photos, maps, and more tourist information, you can read our Myrtle Beach trip maker tool.
Getting from Columbia to Myrtle Beach by car takes about 3 hours. Other options: fly; or take a bus. Traveling from Columbia in May, you will find days in Myrtle Beach are slightly colder (79°F), and nights are about the same (64°F). Finish your sightseeing early on the 11th (Wed) to allow enough time to drive to Pawleys Island.
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To see reviews, photos, maps, and more tourist information, you can read our Myrtle Beach trip maker tool.
Getting from Columbia to Myrtle Beach by car takes about 3 hours. Other options: fly; or take a bus. Traveling from Columbia in May, you will find days in Myrtle Beach are slightly colder (79°F), and nights are about the same (64°F). Finish your sightseeing early on the 11th (Wed) to allow enough time to drive to Pawleys Island.
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Pawleys Island — 5 nights
Pawleys Island is a town in Georgetown County, South Carolina, United States, and the Atlantic coast barrier island on which the town is located.Pawleys Island population was 103 at the 2010 census, down from 138 in 2000. Escape the urban bustle at Caledonia Golf & Fish Club and The Founders Club. You'll discover tucked-away gems like Fishing Charters & Tours and All Saints Church. There's lots more to do: don't miss a visit to Pawleys Island Historic District, see the interesting displays at Georgetown County Museum, look for gifts at Harrelson's Seafood Market, and tee off at Heritage Club.
For maps, photos, reviews, and tourist information, you can read our Pawleys Island road trip website.
Traveling by car from Myrtle Beach to Pawleys Island takes an hour. Alternatively, you can do a combination of bus and taxi. May in Pawleys Island sees daily highs of 80°F and lows of 60°F at night. Finish your sightseeing early on the 16th (Mon) to allow enough time to drive back home.
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For maps, photos, reviews, and tourist information, you can read our Pawleys Island road trip website.
Traveling by car from Myrtle Beach to Pawleys Island takes an hour. Alternatively, you can do a combination of bus and taxi. May in Pawleys Island sees daily highs of 80°F and lows of 60°F at night. Finish your sightseeing early on the 16th (Mon) to allow enough time to drive back home.
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South Carolina travel guide
The Palmetto State
Composed of five distinct geographic regions with boundaries roughly parallel to the Atlantic coastline, South Carolina embraces rich history, scenic beauty, and outstanding cuisine. Originally established as a slave society dependent on the cultivation of rice and indigo, the state now boasts a diverse economy that includes massive production of textile goods, chemical products, machinery, and automobiles. Widely regarded as the beginning of the Deep South, the state remains a deeply conservative part of the country, fervently clinging to its religious and cultural traditions. South Carolinians are kind and open hosts to those who vacation here, eager to share the wealth of their cultural heritage with curious visitors. With many remarkable places to visit like Charleston and Hilton Head, your itinerary here is sure to be diverse and full of scenic attractions.