60 days in Key Largo & Key West Itinerary

Explore the numerous day-trip ideas around Key Largo: Islamorada (Anne's Beach, Old Road Gallery, &more), Everglades National Park (Flamingo & Anhinga Trail) and Homestead (Schnebly Redland's Winery, Everglades Outpost Wildlife Refuge, &more). There's still lots to do: head outdoors with Outdoor Activities, soothe aching muscles at some of the top local wellness centers, get up close and personal with brilliant marine life at Island Dolphin Care, and identify plant and animal life at Dolphin Research Center.

For reviews, traveler tips, other places to visit, and other tourist information, use the Key Largo trip maker app.

Greenville to Key Largo is an approximately 3.5-hour flight. You can also drive; or take a bus. Expect much hotter temperatures when traveling from Greenville in January; daily highs in Key Largo reach 75°F and lows reach 61°F. Wrap up your sightseeing on the 23rd (Thu) to allow time to drive to Key West.

Explore the numerous day-trip ideas around Key West: Islamorada (Alligator Reef Light House, Lignumvitae Key Botanical State Park, &more), Marathon (Sombrero Reef, Seven Mile Bridge, &more) and Big Pine Key (Calusa Beach, Long Beach, &more). Spend the 24th (Fri) exploring nature at Dry Tortugas National Park. There's much more to do: examine the collection at The Ernest Hemingway Home and Museum, don't miss a visit to Southernmost Point, take in the waterfront at Mallory Square, and explore and take pictures at The Overseas Highway.

To see photos, where to stay, other places to visit, and more tourist information, read Key West online trip itinerary builder.

You can drive from Key Largo to Key West in 2.5 hours. Alternatively, you can take a bus. Traveling from Key Largo in February, you can expect nighttime temperatures to be somewhat warmer in Key West, with lows of 68°F. Cap off your sightseeing on the 28th (Tue) early enough to catch the flight back home.