61 days in Southeast Missouri Itinerary

New Madrid is known for museums, sightseeing, and historic sites. Your trip includes some of its best attractions: steep yourself in history at Hunter-Dawson State Historic Site, take in the exciting artwork at New Madrid Historical Museum, get engrossed in the history at Higgerson School Historic Site, and enjoy breathtaking views from Mississippi River Observation Deck.

To find traveler tips, reviews, ratings, and tourist information, go to the New Madrid online trip maker.

Port Harcourt, Nigeria to New Madrid is an approximately 29-hour combination of flight and car. You'll gain 7 hours traveling from Port Harcourt to New Madrid due to the time zone difference. Traveling from Port Harcourt in November, expect New Madrid to be colder, temps between 16°C and 2°C. You will leave for Cape Girardeau on the 1st (Thu).

Explore Cape Girardeau's surroundings by going to Mo-Ark Regional Railroad Museum (in Poplar Bluff) and Sikeston (Sikeston Factory Outlet Stores, Malco Sikeston Cinema and Grill, &more).

To find ratings, where to stay, and other tourist information, read our Cape Girardeau trip planner.

Drive from New Madrid to Cape Girardeau in an hour. Alternatively, you can drive. In December, daily temperatures in Cape Girardeau can reach 9°C, while at night they dip to -1°C. Cap off your sightseeing on the 10th (Sat) early enough to go by car to Sainte Genevieve.

Venture out of the city with trips to Arcadia Valley (in Arcadia) and Bonne Terre (St. Francois State Park, Bonne Terre Mine Tours - West End Diving, &more).

Start your trip to Sainte Genevieve by creating a personalized itinerary on Inspirock.

Traveling by car from Cape Girardeau to Sainte Genevieve takes 1.5 hours. In December, plan for daily highs up to 7°C, and evening lows to -1°C. On the 18th (Sun), wrap the sightseeing up by early afternoon so you can drive to Middle Brook.

Middle Brook is known for nature. Your trip includes some of its best attractions: immerse yourself in nature at Taum Sauk Mountain State Park.

To see other places to visit, photos, and tourist information, go to the Middle Brook trip itinerary maker site.

Traveling by car from Sainte Genevieve to Middle Brook takes 1.5 hours. Alternatively, you can drive. In December, daytime highs in Middle Brook are 7°C, while nighttime lows are -2°C. You'll set off for Eminence on the 26th (Mon).

Explore the numerous day-trip ideas around Eminence: Salem (Montauk State Park & Bo's Hollow), Hydro Adventures (in Poplar Bluff) and West Plains (Ostermeier Brewing Company, Downtown Antiques Mall, &more). Spend the 27th (Tue) exploring nature at Alley Spring Grist Mill Historic Site.

To see reviews, ratings, maps, and more tourist information, go to the Eminence trip builder website.

You can drive from Middle Brook to Eminence in 1.5 hours. In December, daytime highs in Eminence are 10°C, while nighttime lows are -1°C. Finish up your sightseeing early on the 3rd (Tue) so you can go by car to Rolla.

Explore the numerous day-trip ideas around Rolla: New Haven (Astral Glass Studio and Gallery, Robller Vineyard, &more), Leasburg (Belmont Vineyards & Winery, Onondaga Cave State Park, &more) and Steelville (Bass River Resort, Peaceful Bend Vineyard, &more). Make the 6th (Fri) an awe-inspiring day at Mark Twain National Forest.

For more things to do, other places to visit, traveler tips, and more tourist information, use the Rolla trip itinerary planner.

Traveling by car from Eminence to Rolla takes 1.5 hours. January in Rolla sees daily highs of 5°C and lows of -7°C at night. On the 11th (Wed), you'll travel to Eureka.

Get out of town with these interesting Eureka side-trips: New Haven (John Colter Memorial & Pinckney Bend Distillery) and Sullivan (Fisher Cave & Meramec State Park).

Plan a trip to Eureka easily and quickly by telling Inspirock to suggest an itinerary.

You can drive from Rolla to Eureka in 1.5 hours. In January, daytime highs in Eureka are 5°C, while nighttime lows are -7°C. On the 20th (Fri), you're off to home.