7 days in Key Largo & Orlando Itinerary

The northernmost island of the Florida Keys, Key Largo provides stunning scenery, a number of watersports opportunities, and plenty of areas to relax on vacation.

Step off the beaten path and head to The Turtle Hospital and Capt. Sterling's Everglades Eco-Tours. You'll get in some beach time at Sombrero Beach and Sunset Park Beach. Change things up with these side-trips from Key Largo: Marathon (Sombrero Reef & Crane Point Museum & Nature Center). There's still lots to do: see what you can catch with a fishing tour, take in the dramatic natural features at Windley Key Fossil Reef Geological State Park, look for all kinds of wild species at Molasses Reef, and take an in-depth tour of History of Diving Museum.

Before you visit Key Largo, use our trip planner to discover what you can do and see there.

Knoxville to Key Largo is an approximately 4-hour flight. You can also drive; or take a bus. Prepare for somewhat warmer weather when traveling from Knoxville in May: high temperatures in Key Largo hover around 85°F and lows are around 72°F. Cap off your sightseeing on the 18th (Thu) early enough to catch the flight to Orlando.

For most people, any mention of Orlando immediately conjures up images of sprawling theme parks filled with characters plucked right out of popular animated movies.

Start off your visit on the 19th (Fri): identify plant and animal life at Audubon Center for Birds of Prey, explore the world behind art at Charles Hosmer Morse Museum of American Art, then sample the tasty concoctions at Orlando Brewing, and finally shop like a local with International Drive.

For photos, more things to do, where to stay, and other tourist information, read our Orlando day trip tool.

Fly from Key Largo to Orlando in 3 hours. Alternatively, you can drive; or take a bus. In May, plan for daily highs up to 88°F, and evening lows to 69°F. On the 20th (Sat), you'll travel back home.