8 days in Mississippi Itinerary

A busy city on the Gulf Coast, Biloxi is one of the nation's oldest communities, first settled by Europeans in 1699.

On the 19th (Sun), try to win big at Hard Rock Hotel & Casino Biloxi. Keep things going the next day: enjoy the sand and surf at Biloxi Beach, contemplate the long history of Beauvoir, and then try your luck at Beau Rivage Casino.

To see ratings, traveler tips, photos, and other tourist information, read our Biloxi trip planner .

Boston to Biloxi is an approximately 7-hour flight. You can also do a combination of flight and car; or drive. The time zone difference moving from Eastern Standard Time to Central Standard Time is minus 1 hour. Expect somewhat warmer temperatures when traveling from Boston in May; daily highs in Biloxi reach 81°F and lows reach 67°F. Finish up your sightseeing early on the 21st (Tue) so you can go by car to Natchez.

Natchez is the county seat and only city of Adams County, Mississippi, United States. Kick off your visit on the 22nd (Wed): take in the architecture and atmosphere at St. Mary Basilica, make a trip to Longwood, then contemplate the long history of Rosalie Mansion, then take in the spiritual surroundings of First Presbyterian Church, and finally steep yourself in history at Stanton Hall.

To see maps, where to stay, other places to visit, and more tourist information, go to the Natchez journey planner .

You can drive from Biloxi to Natchez in 4.5 hours. Alternatively, you can do a combination of bus, train, and car; or do a combination of bus and car. Traveling from Biloxi in May, you can expect nighttime temperatures to be slightly colder in Natchez, with lows of 61°F. Finish your sightseeing early on the 22nd (Wed) so you can drive to Vicksburg.

Vicksburg is the only city and county seat of Warren County, Mississippi, United States. Start off your visit on the 23rd (Thu): witness the site of a historic battle at Vicksburg National Military Park, then don't miss a visit to Vicksburg Riverfront Murals, then take an in-depth tour of U.S.S. Cairo Museum, and finally get a sense of history and politics at Old Courthouse.

To find maps, traveler tips, photos, and other tourist information, use the Vicksburg tour app .

Traveling by car from Natchez to Vicksburg takes 2 hours. May in Vicksburg sees daily highs of 82°F and lows of 62°F at night. Finish up your sightseeing early on the 23rd (Thu) so you can go by car to Tunica.

Tunica is a town in and the county seat of Tunica County, Mississippi, near the Mississippi River. Start off your visit on the 24th (Fri): see the interesting displays at Blues and Legends Hall of Fame, then try to win big at Gold Strike Casino, and then try your luck at Horseshoe Casino.

To find maps, ratings, more things to do, and tourist information, go to the Tunica online vacation planner .

Traveling by car from Vicksburg to Tunica takes 4 hours. Alternatively, you can do a combination of taxi and train. Expect a daytime high around 78°F in May, and nighttime lows around 59°F. Finish your sightseeing early on the 24th (Fri) so you can drive to Tupelo.

Tupelo is the county seat and the largest city of Lee County, Mississippi. Kick off your visit on the 25th (Sat): grab your bike and head to Natchez Trace Pkwy. On the 26th (Sun), you'll have a packed day of sightseeing: test your team's savvy at popular escape rooms, examine the collection at Tupelo Automobile Museum, and then contemplate the long history of Elvis Presley Birthplace & Museum.

To see photos, where to stay, other places to visit, and other tourist information, go to the Tupelo trip planner .

Getting from Tunica to Tupelo by car takes about 2.5 hours. Other options: do a combination of taxi and bus. In May, plan for daily highs up to 81°F, and evening lows to 59°F. Finish your sightseeing early on the 26th (Sun) so you can travel back home.