8 days in Saint Louis, Memphis & Knoxville Itinerary

8 days in Saint Louis, Memphis & Knoxville Itinerary

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Route & dates

8 days in Saint Louis, Memphis & Knoxville Itinerary

Start: Minneapolis
Fly:  3​h 15​min
1
Saint Louis
— 1 night
+2
Fly + taxi + bus:  4​h 45​min
2
Memphis
— 2 nights
Fly:  5​h 15​min
3
Knoxville
— 3 nights
Fly:  4​h
End: Minneapolis

1
night
Saint Louis

Saint Louis ©
Test the local claim that Saint Louis is second only to Washington, D.C.
Start off your visit on the 5th (Fri): admire nature's wide array of creatures at Saint Louis Zoo and then see the interesting displays at Cardinals Hall of Fame and Museum. Get ready for a full day of sightseeing on the 6th (Sat): take in nature's colorful creations at Missouri Botanical Garden, then get your game on at Top Notch Axe Throwing St. Louis, then enjoy breathtaking views from The Gateway Arch, and finally pause for some serene contemplation at Cathedral Basilica of Saint Louis.

To find more things to do, where to stay, ratings, and more tourist information, use the Saint Louis trip itinerary site .

Minneapolis to Saint Louis is an approximately 3.5-hour flight. You can also drive; or take a bus. When traveling from Minneapolis in July, plan for somewhat warmer days in Saint Louis, with highs around 89°F, while nights are about the same with lows around 68°F. Wrap up your sightseeing on the 6th (Sat) to allow time to travel to Memphis.

Things to do in Saint Louis

Parks Zoos & Aquariums Historic Sites
Highlights from your plan
Cathedral Basilica of Saint Louis ©
The Gateway Arch ©
The Gateway Arch
Top Notch Axe Throwing St. Louis ©
Top Notch Axe Throwing St. Louis

2
nights
Memphis

Memphis ©
The largest city on the Mississippi River, Memphis bills itself as both the "Birthplace of Rock" and "Home of the Blues." With such a rich musical heritage, it shouldn't come as a surprise that Elvis Presley chose to live in Memphis during his later years.
Start off your visit on the 7th (Sun): don't miss a visit to Graceland, admire the masterpieces at Belz Museum of Asian & Judaic Art, and then contemplate the long history of Sun Studio. Get ready for a full day of sightseeing on the 8th (Mon): try to win big at Horseshoe Casino, take an in-depth tour of National Civil Rights Museum - Lorraine Motel, then appreciate the extensive heritage of Beale Street, then stop by Memphis Music, and finally steep yourself in history at The Peabody Ducks.

To find where to stay, other places to visit, photos, and more tourist information, read our Memphis tour builder tool .

You can do a combination of flight and bus from Saint Louis to Memphis in 5 hours. Other options are to drive; or take a bus. Traveling from Saint Louis in July, expect somewhat warmer with lows of 74°F in Memphis. Cap off your sightseeing on the 8th (Mon) early enough to travel to Knoxville.

Things to do in Memphis

Museums Fun & Games Historic Sites

Side Trip

Horseshoe Tunica
Highlights from your plan
Graceland ©
Graceland
Sun Studio ©
Sun Studio

3
nights
Knoxville

Knoxville ©
A gateway to Great Smoky Mountains National Park, Knoxville embraces music culture.
Change things up with these side-trips from Knoxville: Great Smoky Mountains National Park (Roaring Fork & Mount LeConte), Pigeon Forge (Dollywood & Smoky Mountain Alpine Coaster) and Tennessee Legend Distillery - Newport Hwy (in Sevierville). And it doesn't end there: let the river carry you with a rafting and tubing tour, sample the fine beverages at Ole Smoky Tennessee Moonshine, kick your exploration up a notch at some of the top local zipline courses and adventure parks, and admire nature's wide array of creatures at Ripley's Aquarium of the Smokies.

Plan trip to Knoxville with our itinerary maker to find out where to go and what to do.

Traveling by flight from Memphis to Knoxville takes 5.5 hours. Alternatively, you can drive; or take a bus. Traveling from Memphis to Knoxville, you'll lose 1 hour due to the time zone difference. Traveling from Memphis in July, you can expect nighttime temperatures to be slightly colder in Knoxville, with lows of 69°F. Wrap up your sightseeing on the 12th (Fri) early enough to travel back home.

Things to do in Knoxville

Parks Outdoors Adventure

Side Trips

Gatlinburg, Pigeon Forge, Hartford, Great Smoky Mountains National Park, Tennessee Legend Distillery - Newport Hwy
Highlights from your plan
Market Square ©
Market Square
River Rafting & Tubing
Sugarlands Distilling Company ©
Sugarlands Distilling Company

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